Breakthrough peptide-powered formulations deliver clinical results for smoother, firmer, more resilient skin.

Today, HydroPeptide, a pioneer in peptide science and regenerative skincare, announced the launch of two advanced skin health innovations: ReActivate Rx Serum and ReActivate Rx Moisturizer Pro-Collagen Night Complex. Developed for use by licensed skincare professionals, both products feature the proprietary synergy of NIMNI™ Technology and Micellular CellRenew-16™, a patent-pending dual technology that’s the most advanced breakthrough to-date and outperforms exosomes and growth factors in collagen formation, hydration, and fibroblast activation. These cutting-edge formulas deliver powerful, clinically proven results, including a 450% boost in collagen crosslinking, to reinforce skin structure, firmness and elasticity.

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The ReActivate Rx Serum targets the full aging spectrum, visibly improving fine lines, elasticity, tone, and texture, while reducing inflammation and restoring skin’s protective barrier. The ReActivate Rx Moisturizer Pro-Collagen Night Complex contains twice the amino acids found in traditional formulas,* a time-release retinol, biomimetic peptides, and collagen-boosting antioxidants including a stable vitamin C derivative and inflammation-fighting NMN. When used together this powerhouse system works overnight to lift, firm, and restore skin vitality.

"ReActivate Rx represents the culmination of over two decades of peptide innovation and clinical research,” says Annette Rubin, CEO of HydroPeptide. "Regenerative aesthetics has never been more in demand, as consumers shift from chasing quick fixes to proactively strengthening their skin’s foundation. We worked alongside leading scientists to understand not just how to stimulate collagen, but how to sustain and protect it at the cellular level—because that’s where skin health and longevity truly begin. By combining our patented technology with next-generation peptide delivery, we've created a system that doesn’t just treat the signs of aging, it creates the optimal environment for healthy skin cells to thrive."

Grounded in rigorous research, gene expression analysis, and peer-reviewed clinical studies, the ReActivate Rx products are designed to drive meaningful results at the cellular level. Key performance highlights include:

• 200% increase in collagen synthesis activity at 90 hours post-application
• 350% increase in elastin fiber development, helping lift and firm skin
• 300% improvement in dermal architecture, promoting smoother, more resilient texture

"As a provider, I want the best for my patients’ skin and that means, offering products with formulations that improve their overall skin health. Not all skin types are the same and sometimes products in a daily regimen need a boost with a higher concentration to meet patients’ individual needs,” says Kate Cunningham Jeffrey, PA-C, CEO & Co-Founder, Pretty Please Aesthetics. "As one of the first to test the ReActivate Rx system, I took note to the immediate improvement in skin firmness and hydration. The ability to offer the system in my practice is a true advancement in the skincare category, and demonstrates how the products we know, and love can go beyond surface-level for lasting results that elevate the standard of regenerative aesthetics.”

HydroPeptide has long been the go-to name in professional skincare, with results-driven facials trusted by estheticians and medical providers worldwide. The launch of ReActivate Rx extends this treatment-room heritage, complementing advanced offerings like the HydroGlass Experience facial - HydroPeptide’s exclusive medical-grade treatment available only through licensed providers.

Together, the ReActivate Rx Serum and Moisturizer deliver regenerative performance trusted by skincare professionals. Both products will be available exclusively through licensed medical professionals, including dermatologists, aestheticians, and certified aesthetic providers within HydroPeptide’s trusted network of providers.

To find a provider near you and stay informed of availability, visit hydropeptide.com/pages/store-locator. For more information, visit hydropeptide.com and @HydroPeptide on social media.

About HydroPeptide

Since 2004, HydroPeptide has been a leader in regenerative skincare, delivering transformative results through innovative peptide science and advanced delivery technologies. With more than 65 proprietary peptide complexes, HydroPeptide leads the way in clinically clean formulations that improve skin health at the cellular level. Backed by rigorous clinical and consumer testing, HydroPeptide products are trusted by professionals worldwide for their safety, efficacy, and proven performance—all of which meet the highest global standards.

*Compared to the Collagen ReActivate PM Lifting Treatment Moisturizer + Retinol

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