Washington, D.C. 20549
Pursuant to Section 13 OR 15(d) of
The Securities Exchange Act of 1934
March 3, 2010
(Exact name of registrant as specified in its charter)
Delaware   001-32335   88-0488686
(State or other jurisdiction   (Commission   (IRS Employer
of incorporation)   File Number)   Identification No.)
11388 Sorrento Valley Road, San Diego, California   92121
(Address of principal executive offices)   (Zip Code)
Registrant’s telephone number, including area code: (858) 794-8889
Not Applicable
(Former name or former address, if changed since last report.)
Check the appropriate box below if the Form 8-K filing is intended to simultaneously satisfy the filing obligation of the registrant under any of the following provisions (see General Instruction A.2. below):
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o   Pre-commencement communications pursuant to Rule 13e-4(c) under the Exchange Act (17 CFR 240.13e-4(c))



Item 7.01 Regulation FD Disclosure.
     On January 11, 2010, Halozyme Therapeutics, Inc. (“Halozyme”) utilized a Form 8-K to furnish certain slides to be used by Halozyme in making investor presentations to interested parties, including analysts and stockholders (the “January Presentation”). Halozyme wishes to update two of the slides from the January Presentation as attached hereto as Exhibit 99.1, which is incorporated herein by reference. Slides 11 and 39 of the January Presentation are being updated to reflect that a subcutaneous formulation of MabThera® (rituximab) is the identity of the second product candidate under Halozyme’s existing partnership with F. Hoffmann-La Roche, Ltd and Hoffmann-La Roche, Inc. Intravenously administered MabThera is approved for the treatment of non-Hodgkin’s lymphoma (NHL), a type of cancer that affects lymphocytes, or white blood cells. An estimated 66,000 new cases of NHL were diagnosed in the U.S. in 2009 with approximately 125,000 new cases reported worldwide. Additional information about the Phase 1 subcutaneous MabThera clinical trial can be found at clinicaltrials.gov and
     This information is being furnished pursuant to Item 7.01 of this Report and shall not be deemed to be “filed” for the purposes of Section 18 of the Securities and Exchange Act of 1934, as amended, or otherwise subject to the liabilities of that section and will not be incorporated by reference into any registration statement filed by Halozyme, under the Securities Act of 1933, as amended, unless specifically identified as being incorporated therein by reference. This Report will not be deemed an admission as to the materiality of any information in this Report that is being disclosed pursuant to Regulation FD.
     Please refer to page 2 of the January Presentation for a discussion of certain forward-looking statements included therein and the risks and uncertainties related thereto.
Item 9.01 Financial Statements and Exhibits.
(d) Exhibits
Exhibit No.   Description
  Slides 11 and 39 of the January Presentation.



     Pursuant to the requirements of the Securities Exchange Act of 1934, the registrant has duly caused this report to be signed on its behalf by the undersigned hereunto duly authorized.
  Halozyme Therapeutics, Inc.
March 3, 2010  By:   /s/ James E. Cartoni    
    James E. Cartoni   
    Vice President, Legal