Filed Pursuant to Rule 424(b)(3) and (c)
                               File No. 333-94161

                           PROSPECTUS SUPPLEMENT NO. 4
                               DATED MAY 25, 2001
                                       TO
                        PROSPECTUS DATED JANUARY 26, 2000

                        INHALE THERAPEUTIC SYSTEMS, INC.

                                  $108,450,000
                                       OF
                   6 3/4% CONVERTIBLE SUBORDINATED DEBENTURES
                              DUE OCTOBER 13, 2006
                                       AND
                        6,776,536 SHARES OF COMMON STOCK
                   ISSUABLE UPON CONVERSION OF THE DEBENTURES


         This prospectus supplement supplements the prospectus dated January 26,
2000 of Inhale Therapeutic Systems, Inc. relating to the public offering and
sale by selling security holders described below. This prospectus supplement
contains information on ownership of principal amount of debentures beneficially
owned and offered and shares of our common stock issuable upon conversion of the
debentures. This prospectus supplement should be read in conjunction with the
prospectus, and this prospectus supplement is qualified by reference to the
prospectus, except to the extent that the information provided by this
prospectus supplement supersedes the information contained in the prospectus.



         SEE "RISK FACTORS" BEGINNING ON PAGE 3 OF THE PROSPECTUS TO READ ABOUT
FACTORS YOU SHOULD CONSIDER BEFORE BUYING THE DEBENTURES OR OUR COMMON STOCK.

                ------------------------------------------------

         Neither the Securities and Exchange Commission nor any other regulatory
body has approved or disapproved of these securities or passed upon the adequacy
or accuracy of this prospectus. Any representation to the contrary is a criminal
offense.


                                       1.



The table and related footnote on pages 57, 58, 59 and 60 of the prospectus
setting forth information concerning the selling security holders is amended by
the addition of the following information to that table:



---------------------------------- ---------------------- ----------------------- ------------- --------------------
     SELLING SECURITY HOLDER        PRINCIPAL AMOUNT OF   COMMON STOCK ISSUABLE      COMMON     COMMON STOCK OWNED
                                        DEBENTURES          UPON CONVERSION OF       STOCK       AFTER COMPLETION
                                    BENEFICIALLY OWNED    THE DEBENTURES (1)(2)   OFFERED(1)(2)   OF THE OFFERING
                                      AND OFFERED (1)
---------------------------------- ---------------------- ----------------------- ------------- --------------------
                                                                                    
Goldman Sachs and Company                7,000,000               437,396            437,396              -
---------------------------------- ---------------------- ----------------------- ------------- --------------------


------------------

(1)  Amounts indicated may be in excess of the total amount registered due to
     sales or transfers exempt from the registration requirements of the
     Securities Act since the date upon which the selling holders provided to us
     in the information regarding their debentures.
(2)  Inhale's Board of Directors declared a two-for-one split of the outstanding
     shares of our common stock for all holders of record as of the close of
     business on August 1, 2000 which was effected in the form of a stock
     dividend resulting in a reduction by one-half of the conversion price per
     share and an increase in the number of shares of our common stock issuable
     upon conversion of the notes. As of August 2, 2000 the notes became
     convertible at a conversion price of $16.0038 per share. Al stock numbers
     in this supplement have been adjusted to give effect to this two-for-one
     stock split.

     Additional information regarding selling holders will be provided by
amendment or supplement to this prospectus.

     Information concerning the selling holders may change from time to time and
any changed information will be set forth in supplements to this prospectus if
and when necessary. In addition, the conversion rate and therefore, the number
of shares of common stock issuable upon conversion of the debentures, is subject
to adjustment under certain circumstances. Accordingly, the aggregate principal
amount of debentures and the number of shares of common stock into which the
debentures are convertible may increase or decrease.

            The date of this prospectus supplement is May 25, 2001.

                                       2.