UNITED STATES
                       SECURITIES AND EXCHANGE COMMISSION
                             Washington, D.C. 20549


                                  SCHEDULE 13G

                    Under the Securities Exchange Act of 1934

                               (Amendment No. 1)*



                         AVANT IMMUNOTHERAPEUTICS, INC.
--------------------------------------------------------------------------------
                                (Name of Issuer)

                    Common Stock, par value $0.001 per share
--------------------------------------------------------------------------------
                         (Title of Class of Securities)


                                    053491106
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                                 (CUSIP Number)

                                December 31, 2007
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             (Date of Event Which Requires Filing of this Statement)


Check the appropriate box to designate the rule pursuant to  which this Schedule
13G is filed:

         [ ] Rule 13d-1(b)
         [X] Rule 13d-1(c)
         [ ] Rule 13d-1(d)



*The  remainder of this cover page shall be filled out for a reporting  person's
initial filing on this form with respect to the subject class of securities, and
for any  subsequent  amendment  containing  information  which  would  alter the
disclosures provided in a prior cover page.

The information required in the remainder of this cover page shall not be deemed
to be "filed" for the purpose of Section 18 of the  Securities  Exchange  Act of
1934 ("Act") or otherwise  subject to the liabilities of that section of the Act
but  shall be  subject  to all other  provisions  of the Act  (however,  see the
Notes).





CUSIP No.  053491106
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(1)  Names of Reporting Persons:  TSP Capital Management Group, LLC
     I.R.S. Identification Nos. of Above Persons (entities only)


--------------------------------------------------------------------------------

(2)  Check the Appropriate Box if a Member of a Group (See Instructions)
        (a) [ ]
        (b) [X]
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(3)     SEC Use Only
--------------------------------------------------------------------------------

(4)     Citizenship or Place of Organization:   Delaware
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Number of Shares Beneficially Owned
  by Each Reporting Person            (5) Sole Voting Power:                  0*
                                          --------------------------------------
                                      (6) Shared Voting Power:                0*
                                          --------------------------------------
                                      (7) Sole Dispositive Power:             0*
                                          --------------------------------------
                                      (8) Shared Dispositive Power:           0*
                                          --------------------------------------
--------------------------------------------------------------------------------
 (9) Aggregate Amount Beneficially Owned by Each Reporting Person:      0*
--------------------------------------------------------------------------------

(10) Check if the Aggregate Amount in Row (9) Excludes Certain Shares (See
     Instructions):   [ ]
--------------------------------------------------------------------------------

(11) Percent of Class Represented by Amount in Row (9):  0.0%*
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(12) Type of Reporting Person (See Instructions):  IA
--------------------------------------------------------------------------------
* Based on information  set forth on the Form 10-Q of AVANT  Immunotherapeutics,
Inc. (the  "Company") as filed with the  Securities  and Exchange  Commission on
November 7, 2007, there were 74,188,066 shares of common stock, par value $0.001
per share (the  "Shares"),  of the Company issued and outstanding as of November
5, 2007.  As of December 31, 2007 (the  "Reporting Date"),  Thomas S. Paluck and
Dorothy Paluck held 770,000 and 230,000 Shares, respectively. In addition, as of
the Reporting  Date, TSP Capital  Management  Group,  LLC ("TSP") managed one or
more private  investment  accounts on behalf of various  clients  (the  "Managed
Accounts"),  which owned in the aggregate  6,632,346 Shares.  Mr. Paluck is  the
sole  principal of TSP.  Mr. and Mrs. Paluck possess shared power to vote and to
direct the  disposition  of those  Shares  held in their  respective  names.  In






addition,  Mr. Paluck  possesses  sole power to  direct the  disposition  of the
securities held by the Managed Accounts. Thus, as of the Reporting Date, for the
purposes of Reg. Section 240.13d-3, (i) Mr. Paluck may be deemed to beneficially
own  7,632,346  Shares or 10.3% of the Shares issued and  outstanding  as of the
Reporting Date, and (ii) Mrs. Paluck may be deemed to beneficially own 1,000,000
Shares or 1.3% of the Shares issued and  outstanding  as of the Reporting  Date.
Each of the reporting persons hereby expressly disclaims membership in a "group"
under Section  13(d) of the Act and the rules and  regulations  thereunder  with
respect to the Shares  reported  herein,  and this  Schedule  13G/A shall not be
deemed to be an admission that any such  reporting  person is a member of such a
group. THIS SCHEDULE 13G AMENDMENT NO. 1 (THE "AMENDED 13G") AMENDS AND RESTATES
THE   SCHEDULE   13G,   AS   PREVIOUSLY   AMENDED,   WITH   RESPECT   TO   AVANT
IMMUNOTHERAPEUTICS,  INC. FILED WITH THE SECURITIES AND EXCHANGE COMMISSION (THE
"SEC") BY TSP CAPITAL  MANAGEMENT GROUP, LLC (THE "PRIOR 13G"). THIS AMENDED 13G
CORRECTS THE PRIOR 13G AND REPORTS THAT ONLY THOMAS S. PALUCK AND DOROTHY PALUCK
ARE REPORTING  PERSONS WITH RESPECT TO THE SECURITIES  REPORTED IN THE PRIOR 13G
BECAUSE, AS OF THE DATE OF THE TRANSACTIONS REPORTED IN THE PRIOR 13G, THOMAS S.
PALUCK  POSSESSED  THE SOLE  POWER TO DIRECT  THE  DISPOSITION  OF THE  REPORTED
SECURITIES HELD BY SEVERAL PRIVATE INVESTMENT ACCOUNTS (THE "MANAGED ACCOUNTS"),
AND THOMAS S.  PALUCK AND  DOROTHY  PALUCK  POSSESSED  SHARED  POWER TO VOTE AND
SHARED POWER TO DIRECT THE DISPOSITION OF THE REPORTED  SECURITIES HELD IN THEIR
RESPECTIVE NAMES. CONCURRENTLY WITH THE FILING OF THIS AMENDED 13G WITH THE SEC,
THOMAS  S.  PALUCK  AND  DOROTHY  PALUCK  HAVE  CAUSED  A  SCHEDULE  13G AND ALL
APPLICABLE  AMENDMENTS  THERETO TO BE FILED WITH THE SEC UNDER THE CENTRAL INDEX
KEYS FOR THOMAS S. PALUCK AND DOROTHY  PALUCK  DISCLOSING  THAT THOMAS S. PALUCK
POSSESSED THE SOLE POWER TO DIRECT THE  DISPOSITION  OF THE REPORTED  SECURITIES
HELD BY THE MANAGED ACCOUNTS,  AND THOMAS S. PALUCK AND DOROTHY PALUCK POSSESSED
SHARED POWER TO VOTE AND SHARED POWER TO DIRECT THE  DISPOSITION OF THE REPORTED
SECURITIES HELD IN THEIR RESPECTIVE NAMES.






THIS SCHEDULE 13G  AMENDMENT  NO. 1 (THE "AMENDED  13G") AMENDS AND RESTATES THE
SCHEDULE 13G, AS PREVIOUSLY AMENDED,  WITH RESPECT TO AVANT  IMMUNOTHERAPEUTICS,
INC.  FILED WITH THE  SECURITIES  AND  EXCHANGE  COMMISSION  (THE  "SEC") BY TSP
CAPITAL  MANAGEMENT  GROUP, LLC (THE "PRIOR 13G"). THIS AMENDED 13G CORRECTS THE
PRIOR 13G AND  REPORTS  THAT  ONLY  THOMAS  S. PALUCK  AND  DOROTHY  PALUCK  ARE
REPORTING  PERSONS  WITH  RESPECT TO THE  SECURITIES  REPORTED  IN THE PRIOR 13G
BECAUSE, AS OF THE DATE OF THE TRANSACTIONS REPORTED IN THE PRIOR 13G, THOMAS S.
PALUCK  POSSESSED  THE SOLE  POWER TO DIRECT  THE  DISPOSITION  OF THE  REPORTED
SECURITIES HELD BY SEVERAL PRIVATE INVESTMENT ACCOUNTS (THE "MANAGED ACCOUNTS"),
AND THOMAS S. PALUCK AND  DOROTHY  PALUCK  POSSESSED  SHARED  POWER TO  VOTE AND
SHARED POWER TO DIRECT THE DISPOSITION OF THE REPORTED  SECURITIES HELD IN THEIR
RESPECTIVE NAMES. CONCURRENTLY WITH THE FILING OF THIS AMENDED 13G WITH THE SEC,
THOMAS  S. PALUCK  AND  DOROTHY  PALUCK  HAVE  CAUSED  A  SCHEDULE  13G  AND ALL
APPLICABLE  AMENDMENTS  THERETO TO BE FILED WITH THE SEC UNDER THE CENTRAL INDEX
KEYS FOR THOMAS S. PALUCK AND DOROTHY  PALUCK  DISCLOSING  THAT THOMAS S. PALUCK
POSSESSED THE SOLE POWER TO DIRECT THE  DISPOSITION  OF THE REPORTED  SECURITIES
HELD BY THE MANAGED ACCOUNTS,  AND THOMAS S. PALUCK AND DOROTHY PALUCK POSSESSED
SHARED POWER TO VOTE AND SHARED POWER TO DIRECT THE  DISPOSITION OF THE REPORTED
SECURITIES HELD IN THEIR RESPECTIVE NAMES.


Item 1(a).  Name of Issuer:  AVANT Immunotherapeutics, Inc.

Item 1(b).  Address of Issuer's Principal Executive Offices:

            119 Fourth Avenue
            Needham, MA 02494


Item 2(a).  Name of Person Filing:  TSP Capital Management Group, LLC

Item 2(b).  Address of Principal Business Office or, if None, Residence:

            382 Springfield Avenue, Suite 500
            Summit, NJ 07901

Item 2(c).  Citizenship:  Delaware

Item 2(d).  Title of Class of Securities:  Common Stock, par value $0.001 per
            share

Item 2(e).  CUSIP Number:   053491106


Item 3.     If This Statement Is Filed Pursuant to Sections 240.13d-1(b) or
            240.13d-2(b) or (c), check whether the Person Filing is a:

            Not applicable.


Item 4.  Ownership:

         (a) Amount Beneficially Owned:       0*

         (b) Percent of Class:             0.0%*


-------------------
* Based on information  set forth on the Form 10-Q of AVANT  Immunotherapeutics,
Inc. (the  "Company") as filed with the  Securities  and Exchange  Commission on
November 7, 2007, there were 74,188,066 shares of common stock, par value $0.001
per share (the  "Shares"),  of the Company issued and outstanding as of November
5, 2007. As of December 31, 2007 (the  "Reporting  Date"),  Thomas S. Paluck and
Dorothy Paluck held 770,000 and 230,000 Shares, respectively. In addition, as of
the Reporting  Date, TSP Capital  Management  Group,  LLC ("TSP") managed one or
more private  investment  accounts on behalf of various  clients  (the  "Managed
Accounts"),  which owned in the aggregate  6,632,346  Shares.  Mr. Paluck is the
sole principal of TSP.  Mr. and Mrs. Paluck  possess shared power to vote and to
direct the  disposition  of those  Shares  held in their  respective  names.  In
addition,  Mr. Paluck  possesses  sole power to  direct the  disposition  of the
securities held by the Managed Accounts. Thus, as of the Reporting Date, for the
purposes of Reg. Section 240.13d-3, (i) Mr. Paluck may be deemed to beneficially
own  7,632,346  Shares or 10.3% of the Shares issued and  outstanding  as of the
Reporting Date, and (ii) Mrs. Paluck may be deemed to beneficially own 1,000,000
Shares or 1.3% of the Shares issued and  outstanding  as of the Reporting  Date.
Each of the reporting persons hereby expressly disclaims membership in a "group"
under Section  13(d) of the Act and the rules and  regulations  thereunder  with
respect to the Shares  reported  herein,  and this  Schedule  13G/A shall not be
deemed to be an admission that any such  reporting  person is a member of such a
group.





         (c) Number of Shares as to which the person has:

             (i)  sole power to vote or to direct the vote:                  0*

             (ii) shared power to vote or to direct the vote:                0*

            (iii) sole power to dispose or to direct the disposition of:     0*

             (iv) shared power to dispose or to direct the disposition of:   0*



Item 5.  Ownership of Five Percent or Less of a Class:

         Not applicable.


Item 6.  Ownership of More Than Five Percent on Behalf of Another Person:

         Not applicable.


Item 7.  Identification  and  Classification  of the  Subsidiary Which  Acquired
         the Securities:

         Not applicable.




-------------------
* Based on information  set forth on the Form 10-Q of AVANT  Immunotherapeutics,
Inc. (the  "Company") as filed with the  Securities  and Exchange  Commission on
November 7, 2007, there were 74,188,066 shares of common stock, par value $0.001
per share (the  "Shares"),  of the Company issued and outstanding as of November
5, 2007.  As of December 31, 2007 (the  "Reporting Date"),  Thomas S. Paluck and
Dorothy Paluck held 770,000 and 230,000 Shares, respectively. In addition, as of
the Reporting  Date, TSP Capital  Management  Group,  LLC ("TSP") managed one or
more private  investment  accounts on behalf of various  clients  (the  "Managed
Accounts"),  which owned in the aggregate  6,632,346  Shares.  Mr. Paluck is the
sole  principal of TSP.  Mr. and Mrs. Paluck possess shared power to vote and to
direct the  disposition  of those  Shares  held in their  respective  names.  In
addition,  Mr. Paluck  possesses  sole power to  direct the  disposition  of the
securities held by the Managed Accounts. Thus, as of the Reporting Date, for the
purposes of Reg. Section 240.13d-3, (i) Mr. Paluck may be deemed to beneficially
own  7,632,346  Shares or 10.3% of the Shares issued and  outstanding  as of the
Reporting Date, and (ii) Mrs. Paluck may be deemed to beneficially own 1,000,000
Shares or 1.3% of the Shares issued and  outstanding  as of the Reporting  Date.
Each of the reporting persons hereby expressly disclaims membership in a "group"
under Section  13(d) of the Act and the rules and  regulations  thereunder  with
respect to the Shares  reported  herein,  and this  Schedule  13G/A shall not be
deemed to be an admission that any such  reporting  person is a member of such a
group.





Item 8.  Identification and Classification of Members of the Group:

         Not applicable.


Item 9.  Notice of Dissolution of Group:

         Not applicable.


Item 10.  Certification

          By  signing  below I certify  that,  to the best of my  knowledge  and
belief, the securities  referred to above were not acquired and are not held for
the purpose of or with the effect of changing or influencing  the control of the
issuer of the  securities  and were not acquired and are not held in  connection
with or as a participant in any transaction having that purpose or effect.






                                    SIGNATURE

          After reasonable inquiry and to the best of my  knowledge  and belief,
I certify that the information set forth in this statement is true, complete and
correct.


                                    February 26, 2008


                                    TSP CAPITAL MANAGEMENT GROUP, LLC


                                    /s/ Barbara J. Klepper
                                    --------------------------------------------
                                    Barbara J. Klepper, Chief Compliance Officer




      Attention:  Intentional misstatements or omissions of fact constitute
                Federal criminal violations (See 18 U.S.C. 1001)