Ownership Submission
FORM 3
UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

INITIAL STATEMENT OF BENEFICIAL OWNERSHIP OF SECURITIES

Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934, Section 17(a) of the Public Utility Holding Company Act of 1935 or Section 30(h) of the Investment Company Act of 1940
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(Print or Type Responses)
1. Name and Address of Reporting Person *
  Caldarella Joseph C
2. Date of Event Requiring Statement (Month/Day/Year)
10/10/2005
3. Issuer Name and Ticker or Trading Symbol
BRISTOL MYERS SQUIBB CO [(BMY)]
(Last)
(First)
(Middle)
BRISTOL-MYERS SQUIBB COMPANY, ROUTE 206 & PROVINCELINE ROAD
4. Relationship of Reporting Person(s) to Issuer
(Check all applicable)
_____ Director _____ 10% Owner
__X__ Officer (give title below) _____ Other (specify below)
VP & Financial Controller
5. If Amendment, Date Original Filed(Month/Day/Year)
(Street)

PRINCETON, NJ 08543
6. Individual or Joint/Group Filing(Check Applicable Line)
_X_ Form filed by One Reporting Person
___ Form filed by More than One Reporting Person
(City)
(State)
(Zip)
Table I - Non-Derivative Securities Beneficially Owned
1.Title of Security
(Instr. 4)
2. Amount of Securities Beneficially Owned
(Instr. 4)
3. Ownership Form: Direct (D) or Indirect (I)
(Instr. 5)
4. Nature of Indirect Beneficial Ownership
(Instr. 5)
Common Stock, $0.10 par value 18,481 (1)
D
 
Common Stock, $0.10 par value 2,442.45
I
By BMY Savings & Investment Program (2)

Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly. SEC 1473 (7-02)
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Table II - Derivative Securities Beneficially Owned (e.g., puts, calls, warrants, options, convertible securities)
1. Title of Derivative Security
(Instr. 4)
2. Date Exercisable and Expiration Date
(Month/Day/Year)
3. Title and Amount of Securities Underlying Derivative Security
(Instr. 4)
4. Conversion or Exercise Price of Derivative Security 5. Ownership Form of Derivative Security: Direct (D) or Indirect (I)
(Instr. 5)
6. Nature of Indirect Beneficial Ownership
(Instr. 5)
Date Exercisable Expiration Date Title Amount or Number of Shares
Executive Option (right to buy) 01/04/2000(3) 01/03/2009 Common Stock, $0.10 par value 17,878 $ 62.95 D  
Executive Option (right to buy)   (3) 01/02/2010 Common Stock, $0.10 par value 1,788 $ 61.09 D  
Executive Option (right to buy) 03/06/2002(3) 03/05/2011 Common Stock, $0.10 par value 15,775 $ 59.78 D  
Option (right to buy)   (4) 03/04/2006 Common Stock, $0.10 par value 21,033 $ 20.74 D  
Option (right to buy) 03/04/1998(4) 03/03/2007 Common Stock, $0.10 par value 15,775 $ 32 D  
Option (right to buy) 03/03/1999(4) 03/02/2008 Common Stock, $0.10 par value 22,400 $ 48.45 D  
Option (right to buy) 03/07/2001(5) 03/06/2010 Common Stock, $0.10 par value 18,930 $ 42.64 D  
Option (right to buy) 03/05/2003(5) 03/04/2012 Common Stock, $0.10 par value 18,000 $ 48.08 D  
Option (right to buy) 06/04/2005(6) 06/03/2007 Common Stock, $0.10 par value 13,500 $ 28.9 D  
Option (right to buy) 03/04/2004(5) 03/03/2013 Common Stock, $0.10 par value 24,138 $ 23.14 D  
Option (right to buy)   (5) 03/01/2014 Common Stock, $0.10 par value 16,500 $ 28.11 D  
Option (right to buy)   (5) 02/28/2015 Common Stock, $0.10 par value 13,781 $ 25.45 D  

Reporting Owners

Reporting Owner Name / Address Relationships
Director 10% Owner Officer Other
Caldarella Joseph C
BRISTOL-MYERS SQUIBB COMPANY
ROUTE 206 & PROVINCELINE ROAD
PRINCETON, NJ 08543
      VP & Financial Controller  

Signatures

/s/ Caldarella, Joseph C. 10/12/2005
**Signature of Reporting Person Date

Explanation of Responses:

* If the form is filed by more than one reporting person, see Instruction 5(b)(v).
** Intentional misstatements or omissions of facts constitute Federal Criminal Violations. See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
(1) Includes shares of restricted stock with one-third vesting on each of the third, fourth and fifth anniversaries of the grant date.
(2) Based on a plan statement as of the end of the most recent fiscal quarter.
(3) One half of the shares is exercisable 25% per year, on a cumulative basis, commencing one year after the date of grant. The other half of the shares vests 25% per year and is exercisable on the earlier to occur of (i) the closing share price achieving a price threshold and remaining at that threshold for a given number of days or (ii) the eighth anniversary of the grant date.
(4) Currently Exercisable.
(5) Exercisable as to 25% of the shares annually, on a cumulative basis, commencing one year after the date of grant.
(6) Exercisable on the earlier of (i) three years from the date of grant or (ii) the date on which the closing share price achieves $50.00 or above for seven consecutive trading days.

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