CUSIP No. 03152W109

13G/A

Page 7 of 11 Pages

David J. Morrison (“Morrison”) is the record owner of 55,845 shares of Common Stock (the “Morrison Shares”). Great Point is the investment manager with respect to the Morrison Shares, and by virtue of such status may be deemed to be the beneficial owner of the Morrison Shares. Each of Dr. Jay, as senior managing member of Great Point, and Mr. Kroin, as special managing member of Great Point, has voting and investment power with respect to the Morrison Shares, and therefore may be deemed to be the beneficial owner of the Morrison Shares. In addition, Morrison is the record owner of a warrant to purchase 28,901 shares.

WS Investments III, LLC (“WS”) is the record owner of 352,940 shares of Common Stock (the “WS Shares”). Great Point is the investment manager with respect to the WS Shares, and by virtue of such status may be deemed to be the beneficial owner of the WS Shares. Each of Dr. Jay, as senior managing member of Great Point, and Mr. Kroin, as special managing member of Great Point, has voting and investment power with respect to the WS Shares, and therefore may be deemed to be the beneficial owner of the WS Shares. In addition, WS is the record owner of a warrant to purchase 176,470 shares.

The provisions of the warrants described above restrict the exercise of such warrants to the extent that, after giving effect to such exercise, the holder of the warrants and its affiliates and any other person or entities with which such holder would constitute a group would beneficially own in excess of 9.99% of the number of shares of Common Stock of the Issuer outstanding immediately after giving effect to such exercise (the “Ownership Cap”).

Notwithstanding the above, Great Point, Dr. Jay and Mr. Kroin disclaim beneficial ownership of the BVF Shares, the BOVF Shares, the BIVF Shares, the Lyrical Shares, the GEF-PS Shares, the Morrison Shares, the WS Shares and the shares underlying the warrants described above, except to the extent of their respective pecuniary interests.

Provide the following information regarding the aggregate number and percentage of the class of securities of the issuer identified in Item 1.

1.

Great Point Partners, LLC

(a)

Amount beneficially owned: 7,909,706³

(b)

Percent of class: 9.72%^{3, 4}

³

Consists of 2,317,442 shares owned by Biomedical Value Fund, LP (“BVF”), 2,229,854 shares owned by Biomedical Offshore Value Fund, Ltd. (“BOVF”), 719,770 shares owned by Biomedical Institutional Value Fund, LP (“BIVF”), 837,696 shares owned by Lyrical Multi-Manager Fund, LP (“Lyrical”), 1,396,159 shares owned by Class D Series of GEF-PS, LP (“GEF-PS”), 55,845 shares owned by David J. Morrison (“Morrison”) and 352,940 shares owned by WS Investments III, LLC (“WS”). Does not include 1,077,763 shares underlying a warrant held by BVF, 995,945 shares underlying a warrant held by BOVF, 308,277 shares underlying a warrant held by BIVF, 433,526 shares underlying a warrant held by Lyrical, 722,543 shares underlying a warrant held by GEF-PS, 28,901 shares underlying a warrant held by Morrison and 176,470 shares underlying a warrant held by WS. The provisions of such warrants restrict the exercise of such warrants to the extent that, after giving effect to such exercise, the holder of the warrants and its affiliates and any other persons or entities with which such holder would constitute a group would beneficially own in excess of 9.99% of the number of shares of Common Stock of the Issuer outstanding immediately after giving effect to such exercise (the “Ownership Cap”). Therefore, the reporting persons could be deemed to beneficially own such number of shares underlying such warrants as would result in total beneficial ownership by such reporting persons of up to the Ownership Cap.