Explanatory Note  

Item 1.      Security and Issuer.

   The name of the issuer is of BioMarin Pharmaceutical, Inc., a Delaware corporation (the "Issuer"). The address of the Issuer’s principal executive offices is 105 Digital Drive, Novato, California 94949. This Schedule 13D relates to the Issuer’s common stock, par value $0.001 per share (the "Common Stock").

Item 2.      Identity and Background.

   (a)-(c), (f).  This statement is being filed by Millenco LLC, a Delaware limited liability company ("Millenco"), Integrated Core Strategies (US) LLC, a Delaware limited liability company ("Integrated Core Strategies"), and Catapult Partners, Ltd., an exempted limited company organized under the laws of the Cayman Islands ("Catapult Partners"). Millenco is a broker-dealer and a member of the American Stock Exchange and the NASDAQ.

   Millennium Management LLC, a Delaware limited liability company ("Millennium Management"), is the manager of Millenco, and may be deemed to have shared voting control and investment discretion over securities owned by Millenco. Millennium Management is also the general partner of the managing member of Integrated Core Strategies and may be deemed to have shared voting control and investment discretion over securities owned by Integrated Core Strategies. Millennium Management is also the general partner of the 100% shareholder of Catapult Partners, and may be deemed to have shared voting control and investment discretion over securities owned by Catapult Partners.

   Catapult Capital Management LLC, a Delaware limited liability company ("Catapult Capital Management"), is the investment manager to Catapult Partners, and may be deemed to have shared voting control and investment discretion over securities owned by Catapult Partners. Millennium International Management LP, a Delaware limited partnership ("Millennium International Management"), is the managing member of Catapult Capital Management, and consequently may be deemed to have shared voting control and investment discretion over securities owned by Catapult Partners. Millennium International Management GP LLC, a Delaware limited liability company ("Millennium International Management GP"), is the general partner of Millennium International Management and consequently may be deemed to have shared voting control and investment discretion over securities owned by Catapult Partners.

   Israel A. Englander ("Mr. Englander"), is the managing member of Millennium Management and Millennium International Management GP. Consequently, Mr. Englander may also be deemed to be the beneficial owner of any securities owned by Millenco, Integrated Core Strategies and/or Cognizant Holdings, as the case may be.

   The foregoing should not be construed in and of itself as an admission by Catapult Capital Management, Millennium International Management, Millennium International Management GP, Millennium Management or Mr. Englander as to the shares of the Issuer’s Common Stock beneficially owned by Millenco, Integrated Core Strategies and/or Catapult Partners, as the case may be.

   Millenco, Integrated Core Strategies, Catapult Partners, Catapult Capital Management, Millennium International Management and Millennium International Management GP, Millennium Management and Mr. Englander will be collectively referred to as the reporting persons ("Reporting Persons") in this Schedule 13D.

   The business address for Millenco, Integrated Core Strategies and Mr. Englander is c/o Millennium Management LLC, 666 Fifth Avenue, New York, New York 10103. The business address for Catapult Partners, Catapult Capital Management and Millennium International Management is c/o Millennium International Management GP, 666 Fifth Avenue, New York, New York 10103. The business address for Millennium Management and Millennium International Management GP is 666 Fifth Avenue, New York, New York 10103. Mr. Englander is a United States citizen.

   (d)  During the last five years, none of the Reporting Persons has been convicted in a criminal proceeding (excluding traffic violations or similar misdemeanors).

   (e)  On December 1, 2005, Millennium Management and Mr. Englander, together with Millennium Partners, L.P. ("Millennium Partners") and certain related persons and entities, entered into settlements with the Securities and Exchange Commission ("SEC") and the Attorney General of the State of New York (the "NYAG") relating to allegations that Millennium Partners had engaged in a pattern of deceptive "market timing" of mutual fund shares in years prior to 2004 and, in the case of the settlement with the NYAG only, had failed to take adequate steps to prevent a trader from engaging in mutual fund "late trading" in violation of firm policy. The parties neither admitted nor denied the allegations or findings (except as to jurisdiction) but consented to the entry of findings. The SEC proceedings are In the Matter of Millennium Partners, L.P., et al. Securities Act Release No. 8639 (December 1, 2005), available at www.sec.gov. Contemporaneously, the NYAG issued an Assurance of Discontinuance relating to the claims and findings of that office.

   Neither the Reporting Persons nor any other party admitted or denied any of the allegations or findings in these matters. The remedies included disgorgement by the entities of approximately $148 million of mutual fund trading profits, civil penalties aggregating approximately $32.15 million (with approximately $30 million being paid by Mr. Englander), an administrative order to cease and desist from violations of the antifraud provisions of the Securities Act of 1933 and the Securities Exchange Act of 1934 (the "Exchange Act"), and prophylactic relief.

Item 3.      Source and Amount of Funds or Other Consideration.

   The amount of funds used to purchase the 1,631,007, 3,838,964 and 100,000 shares of the Issuer’s Common Stock held by Millenco, Integrated Core Strategies and Catapult Partners was approximately, $19,164,628, $44,986,501 and $1,256,255, respectively, calculated on an average cost basis (excluding brokerage commissions) by account. Millenco, Integrated Core Strategies and Catapult Partners effect purchases of securities primarily through margin accounts maintained for them with prime brokers, which may extend margin credit to Millenco, Integrated Core Strategies and Catapult Partners as and when required to open or carry positions in the margin accounts, subject to applicable margin regulations, stock exchange rules and the prime broker’s credit policies. In such instances, the positions held in the margin accounts are pledged as collateral security for the repayment of debit balances in the accounts.

Item 4.       Purpose of Transaction.

   The Reporting Persons are engaged in the investment business. In pursuing this business, the Reporting Persons analyze the operations, capital structure and markets of companies, including the Issuer, on a continuous basis, through analysis of documentation and discussions with knowledgeable industry and market observers and with representatives of such companies (often at the invitation of management). From time to time, one or more of the Reporting Persons may hold discussions with third parties or with management of such companies in which the Reporting Persons may suggest or take a position with respect to potential changes in the operations, management or capital structure of such companies as a means of enhancing shareholder value. Such suggestions or positions may relate to one or more of the transactions specified in clauses (a) through (j) of Item 4 of Schedule 13D of the Exchange Act, including, without limitation, such matters as disposing of or selling all or a portion of the company or acquiring another company or business, changing operating or marketing strategies, adopting or not adopting certain types of anti-takeover measures and restructuring the Issuer’s capitalization or dividend policy.

   The Reporting Persons employ the services of a number of portfolio managers, each of whom independently employs a separate and distinct trading strategy. A portion of the securities of the Issuer held by the Reporting Persons are held in accounts of the Reporting Persons managed by portfolio managers who engage in event-, risk- or merger-arbitrage or fundamental strategies.

   Except as set forth above, the Reporting Persons do not have any present plans or proposals that relate to or would result in any of the actions required to be described in Item 4 of this Schedule 13D. Each of the Reporting Persons may, at any time, review or reconsider its position with respect to the Issuer and formulate plans or proposals with respect to any of such matters, but has no present intention of doing so.

Item 5.      Interest in Securities of the Issuer.

   (a)  As of the date this filing: Millenco is the beneficial owner of 1,631,007 shares of the Issuer’s Common Stock; Integrated Core Strategies is the beneficial owner of 3,838,964 shares of the Issuer’s Common Stock; and Catapult Partners is the beneficial owner of 100,000 shares of the Issuer’s Common Stock.

   Millennium Management, as the manager of Millenco, may be deemed to beneficially own the above-described shares of the Issuer’s Common Stock beneficially owned by Millenco. Millennium Management, as the general partner of the managing member of Integrated Core Strategies, may be deemed to beneficially own the above-described shares of the Issuer’s Common Stock beneficially owned by Integrated Core Strategies. In addition, Millennium Management, as the general partner of the 100% shareholder of Catapult Partners, may be deemed to beneficially own the above-described shares of the Issuer’s Common Stock beneficially owned by Catapult Partners.

   Catapult Capital Management, as the investment manager to Catapult Partners, may be deemed to beneficially own the above-described shares of the Issuer’s Common Stock beneficially owned by Catapult Partners. Millennium International Management, as the managing member of Catapult Capital Management, may be deemed to beneficially own the above-described shares of the Issuer’s Common Stock beneficially owned by Catapult Partners. Millennium International Management GP, as the general partner of Millennium International Management, may also be deemed to beneficially own the above-described shares of the Issuer’s Common Stock beneficially owned by Catapult Partners.

   Mr. Englander, as the managing member of Millennium Management and Millennium International Management GP, may also be deemed to beneficially own the above-described shares of the Issuer’s Common Stock beneficially owned by Millenco, Integrated Core Strategies and Catapult Partners.

   Accordingly, as of the date of this filing, Mr. Englander and Millennium Management may be deemed to be beneficial owners of 5,569,971 shares or 5.6% of the Issuer’s Common Stock. The calculation of the foregoing percentage is on the basis of 99,961,086 shares of the Issuer’s Common Stock outstanding as of March 23, 2009, as per the Issuer’s proxy statement dated April 3, 2009. The foregoing should not be construed in and of itself as an admission by Millennium Management or Mr. Englander as to beneficial ownership of the shares held by Millenco, Integrated Core Strategies and/or Catapult Partners, as the case may be.

   (b)  Millenco may be deemed to hold shared power to vote and to dispose of the 1,631,007 shares of the Issuer’s Common Stock described in (a) above. Integrated Core Strategies may be deemed to hold shared power to vote and dispose of the 3,838,964 shares of the Issuer’s Common Stock described in (a) above. Catapult Partners, Catapult Capital Management, Millennium International Management and Millennium International Management GP may be deemed to hold shared power to vote and to dispose of the 100,000 shares of the Issuer’s Common Stock. Mr. Englander and Millennium Management may be deemed to hold shared power to vote and to dispose of the 5,569,971 shares of the Issuer’s Common Stock. The foregoing should not be construed in and of itself as an admission by Catapult Capital Management, Millennium International Management, Millennium International Management GP, Millennium Management or Mr. Englander as to the shares of the Issuer’s Common Stock beneficially owned by Millenco, Integrated Core Strategies and/or Catapult Partners, as the case may be.

   (c)  Transactions in the Issuer’s Common Stock during the past 60 days: Schedule A annexed hereto lists all transactions in the Issuer’s Common Stock by the Reporting Persons. All of the transactions in the Issuer’s Common Stock were effected by either Millenco, Integrated Core Strategies or Catapult Partners in the open market.

   (d)  Transactions in the Issuer’s Common Stock during the past 60 days: Schedule A annexed hereto lists all transactions in the Issuer’s Common Stock by the Reporting Persons. All of the transactions in the Issuer’s Common Stock were effected by either Millenco, Integrated Core Strategies, Catapult Partners or Cognizant Holdings, Ltd., an affiliate of the Reporting Persons, in the open market.

Item 6.      Contracts, Arrangements, Understandings or Relationships with Respect to Securities of the Issuer.

   Cognizant Holdings, Ltd., an affiliate of the Reporting Persons, has an open short position of 459 shares of the Issuer’s Common Stock, which position is not netted against the data provided herein for the purposes of determing the number of shares beneficially owned by any of the Reporting Persons.

   In connection with arrangements with Millenco’s, Integrated Core Strategies’ and Catapult Partners’ prime brokers, such prime brokers are permitted to lend securities in Millenco’s, Integrated Core Strategies’ and Catapult Partners’ accounts to the extent permitted by debit balances in such accounts. Millenco, Integrated Core Strategies and Catapult Partners generally will not have any knowledge of the specific loans made by such prime brokers. In addition, in the ordinary course of business, Millenco, Integrated Core Strategies and Catapult Partners (or their prime brokers), may borrow securities to satisfy delivery obligations arising from short sales. In addition, Millenco may lend securities to third parties and such loans generally may be recalled upon demand, but may not be able to be recalled in advance of an applicable record date and thus, such loaned shares may not be able to be voted by Millenco. Similarly, it should also be noted that shares lent by Millenco’s, Integrated Core Strategies’, Catapult Partners’ prime brokers may not be able to be recalled in advance of an applicable record date and thus, such loaned shares may not be able to be voted by Millenco, Integrated Core Strategies or Catapult Partners, as the case may be.

   There are no other contracts, arrangements, understandings or relationships among the Reporting Persons, or between the Reporting Persons and any other person, with respect to the securities of the Issuer.

Item 7.      Material to Be Filed as Exhibits.

   Exhibit I:  Joint Filing Agreement, dated as of April 9, 2009, by and among Millenco LLC, Integrated Core Strategies (US) LLC, Catapult Partners, Ltd., Catapult Capital Management LLC, Millennium International Management LP, Millennium International Management GP LLC, Millennium Management LLC and Israel A. Englander.

SIGNATURE

   After reasonable inquiry and to the best of my knowledge and belief, I certify that the information set forth in this statement is true, complete and correct.