Ownership Submission
FORM 4
Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).
UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP OF SECURITIES

Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934, Section 17(a) of the Public Utility Holding Company Act of 1935 or Section 30(h) of the Investment Company Act of 1940
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(Print or Type Responses)
1. Name and Address of Reporting Person *
GALAKATOS NICHOLAS
  2. Issuer Name and Ticker or Trading Symbol
PORTOLA PHARMACEUTICALS INC [PTLA]
5. Relationship of Reporting Person(s) to Issuer
(Check all applicable)
__X__ Director _____ 10% Owner
_____ Officer (give title below) _____ Other (specify below)
(Last)
(First)
(Middle)
C/O MPM ASSET MANAGEMENT, 200 CLARENDON STREET, 54TH FLOOR
3. Date of Earliest Transaction (Month/Day/Year)
05/28/2013
(Street)

BOSTON, MA 02116
4. If Amendment, Date Original Filed(Month/Day/Year)
6. Individual or Joint/Group Filing(Check Applicable Line)
_X_ Form filed by One Reporting Person
___ Form filed by More than One Reporting Person
(City)
(State)
(Zip)
Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned
1.Title of Security
(Instr. 3)
2. Transaction Date (Month/Day/Year) 2A. Deemed Execution Date, if any (Month/Day/Year) 3. Transaction Code
(Instr. 8)
4. Securities Acquired (A) or Disposed of (D)
(Instr. 3, 4 and 5)
5. Amount of Securities Beneficially Owned Following Reported Transaction(s)
(Instr. 3 and 4)
6. Ownership Form: Direct (D) or Indirect (I)
(Instr. 4)
7. Nature of Indirect Beneficial Ownership
(Instr. 4)
Code V Amount (A) or (D) Price
Common Stock 05/28/2013   C   39,344 A (1) (2) (3) (4) 39,344 I MPM Asset Management Investors 2003 BVIII LLC (5)
Common Stock 05/28/2013   C   171,747 A (1) (2) (3) (4) 171,747 I MPM Bioventures III GmbH & Co. Beteiligungs KG (5)
Common Stock 05/28/2013   C   61,373 A (1) (2) (3) (4) 61,373 I MPM BioVentures III Parallel Fund, L.P. (5)
Common Stock 05/28/2013   C   136,641 A (1) (2) (3) (4) 136,641 I MPM BioVentures III, L.P. (5)
Common Stock 05/28/2013   C   2,032,239 A (1) (2) (3) (4) 2,032,239 I MPM BioVentures III-QP, L.P. (5)

Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.
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Table II - Derivative Securities Acquired, Disposed of, or Beneficially Owned
(e.g., puts, calls, warrants, options, convertible securities)
1. Title of Derivative Security
(Instr. 3)
2. Conversion or Exercise Price of Derivative Security 3. Transaction Date (Month/Day/Year) 3A. Deemed Execution Date, if any (Month/Day/Year) 4. Transaction Code
(Instr. 8)
5. Number of Derivative Securities Acquired (A) or Disposed of (D)
(Instr. 3, 4, and 5)
6. Date Exercisable and Expiration Date
(Month/Day/Year)
7. Title and Amount of Underlying Securities
(Instr. 3 and 4)
8. Price of Derivative Security
(Instr. 5)
9. Number of Derivative Securities Beneficially Owned Following Reported Transaction(s)
(Instr. 4)
10. Ownership Form of Derivative Security: Direct (D) or Indirect (I)
(Instr. 4)
11. Nature of Indirect Beneficial Ownership
(Instr. 4)
Code V (A) (D) Date Exercisable Expiration Date Title Amount or Number of Shares
Series A Preferred Stock (1) 05/28/2013   C     15,642   (1)   (6) Common Stock 15,642 $ 0 0 I MPM Asset Management Investors 2003 BVIII LLC (5)
Series A Preferred Stock (1) 05/28/2013   C     68,280   (1)   (6) Common Stock 68,280 $ 0 0 I MPM Bioventures III GmbH & Co. Beteiligungs KG (5)
Series A Preferred Stock (1) 05/28/2013   C     24,400   (1)   (6) Common Stock 24,400 $ 0 0 I MPM BioVentures III Parallel Fund, L.P. (5)
Series A Preferred Stock (1) 05/28/2013   C     54,323   (1)   (6) Common Stock 54,323 $ 0 0 I MPM BioVentures III, L.P. (5)
Series A Preferred Stock (1) 05/28/2013   C     807,939   (1)   (6) Common Stock 807,939 $ 0 0 I MPM BioVentures III-QP, L.P. (5)
Series B Preferred Stock (2) 05/28/2013   C     10,710   (2)   (6) Common Stock 10,710 $ 0 0 I MPM Asset Management Investors 2003 BVIII LLC (5)
Series B Preferred Stock (2) 05/28/2013   C     46,752   (2)   (6) Common Stock 46,752 $ 0 0 I MPM Bioventures III GmbH & Co. Beteiligungs KG (5)
Series B Preferred Stock (2) 05/28/2013   C     16,707   (2)   (6) Common Stock 16,707 $ 0 0 I MPM BioVentures III Parallel Fund, L.P. (5)
Series B Preferred Stock (2) 05/28/2013   C     37,196   (2)   (6) Common Stock 37,196 $ 0 0 I MPM BioVentures III, L.P. (5)
Series B Preferred Stock (2) 05/28/2013   C     553,204   (2)   (6) Common Stock 553,204 $ 0 0 I MPM BioVentures III-QP, L.P. (5)
Series C Preferred Stock (3) 05/28/2013   C     10,658   (3)   (6) Common Stock 10,658 $ 0 0 I MPM Asset Management Investors 2003 BVIII LLC (5)
Series C Preferred Stock (3) 05/28/2013   C     46,526   (3)   (6) Common Stock 46,526 $ 0 0 I MPM Bioventures III GmbH & Co. Beteiligungs KG (5)
Series C Preferred Stock (3) 05/28/2013   C     16,625   (3)   (6) Common Stock 16,625 $ 0 0 I MPM BioVentures III Parallel Fund, L.P. (5)
Series C Preferred Stock (3) 05/28/2013   C     37,016   (3)   (6) Common Stock 37,016 $ 0 0 I MPM BioVentures III, L.P. (5)
Series C Preferred Stock (3) 05/28/2013   C     550,530   (3)   (6) Common Stock 550,530 $ 0 0 I MPM BioVentures III-QP, L.P. (5)
Series D Preferred Stock (4) 05/28/2013   C     2,334   (4)   (6) Common Stock 2,334 $ 0 0 I MPM Asset Management Investors 2003 BVIII LLC (5)
Series D Preferred Stock (4) 05/28/2013   C     10,189   (4)   (6) Common Stock 10,189 $ 0 0 I MPM Bioventures III GmbH & Co. Beteiligungs KG (5)
Series D Preferred Stock (4) 05/28/2013   C     3,641   (4)   (6) Common Stock 3,641 $ 0 0 I MPM BioVentures III Parallel Fund, L.P. (5)
Series D Preferred Stock (4) 05/28/2013   C     8,106   (4)   (6) Common Stock 8,106 $ 0 0 I MPM BioVentures III, L.P. (5)
Series D Preferred Stock (4) 05/28/2013   C     120,566   (4)   (6) Common Stock 120,566 $ 0 0 I MPM BioVentures III-QP, L.P. (5)

Reporting Owners

Reporting Owner Name / Address Relationships
 Director  10% Owner  Officer  Other
GALAKATOS NICHOLAS
C/O MPM ASSET MANAGEMENT
200 CLARENDON STREET, 54TH FLOOR
BOSTON, MA 02116
  X      

Signatures

 /s/ Sally A. Kay, as attorney-in-fact   05/28/2013
**Signature of Reporting Person Date

Explanation of Responses:

* If the form is filed by more than one reporting person, see Instruction 4(b)(v).
** Intentional misstatements or omissions of facts constitute Federal Criminal Violations. See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
(1) Upon the closing of the Issuer's initial public offering, each share of Series A Preferred Stock automatically converted into 1 share of Common Stock for no additional consideration and had no expiration date.
(2) Upon the closing of the Issuer's initial public offering, each share of Series B Preferred Stock automatically converted into 1 share of Common Stock for no additional consideration and had no expiration date.
(3) Upon the closing of the Issuer's initial public offering, each share of Series C Preferred Stock automatically converted into 1 share of Common Stock for no additional consideration and had no expiration date.
(4) Upon the closing of the Issuer's initial public offering, each share of Series D Preferred Stock automatically converted into 1 share of Common Stock for no additional consideration and had no expiration date.
(5) MPM BioVentures III GP, L.P. and MPM BioVentures III LLC ("MPM III LLC") are the direct and indirect general partners of MPM BioVentures III, L.P., MPM BioVentures III-QP, L.P., MPM BioVentures III GmbH & Co. Beteiligungs KG and MPM BioVentures III Parallel Fund, L.P. Dr. Galakatos is a Series A member of MPM BioVentures III LLC and Manager of MPM Asset Management Investors 2003 BVIII LLC and shares voting and dispositive power over the shares held by MPM BioVentures III, L.P., MPM BioVentures III-QP, L.P., MPM BioVentures III GmbH & Co. Beteiligungs KG, MPM BioVentures III Parallel Fund, L.P. and MPM Asset Management Investors 2003 BVIII LLC. Dr. Galakatos disclaims beneficial ownership of the shares identified in this footnote except to the extent of his respective proportionate pecuniary interest in such shares.
(6) The shares do not have an expiration date.

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