Ownership Submission
FORM 3
UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

INITIAL STATEMENT OF BENEFICIAL OWNERSHIP OF SECURITIES

Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934, Section 17(a) of the Public Utility Holding Company Act of 1935 or Section 30(h) of the Investment Company Act of 1940
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(Print or Type Responses)
1. Name and Address of Reporting Person *
  THOMAS MCNERNEY & PARTNERS LP
2. Date of Event Requiring Statement (Month/Day/Year)
11/22/2010
3. Issuer Name and Ticker or Trading Symbol
ZOGENIX, INC. [ZGNX]
(Last)
(First)
(Middle)
60 SOUTH 6TH STREET, SUITE 3620
4. Relationship of Reporting Person(s) to Issuer
(Check all applicable)
_____ Director __X__ 10% Owner
_____ Officer (give title below) _____ Other (specify below)
5. If Amendment, Date Original Filed(Month/Day/Year)
(Street)

MINNEAPOLIS, MN 55402
6. Individual or Joint/Group Filing(Check Applicable Line)
___ Form filed by One Reporting Person
_X_ Form filed by More than One Reporting Person
(City)
(State)
(Zip)
Table I - Non-Derivative Securities Beneficially Owned
1.Title of Security
(Instr. 4)
2. Amount of Securities Beneficially Owned
(Instr. 4)
3. Ownership Form: Direct (D) or Indirect (I)
(Instr. 5)
4. Nature of Indirect Beneficial Ownership
(Instr. 5)

Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly. SEC 1473 (7-02)
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Table II - Derivative Securities Beneficially Owned (e.g., puts, calls, warrants, options, convertible securities)
1. Title of Derivative Security
(Instr. 4)
2. Date Exercisable and Expiration Date
(Month/Day/Year)
3. Title and Amount of Securities Underlying Derivative Security
(Instr. 4)
4. Conversion or Exercise Price of Derivative Security 5. Ownership Form of Derivative Security: Direct (D) or Indirect (I)
(Instr. 5)
6. Nature of Indirect Beneficial Ownership
(Instr. 5)
Date Exercisable Expiration Date Title Amount or Number of Shares
Stock Purchase Warrant (right to buy) 12/02/2009   (3) Series B Convertible Preferred Stock 3,910 $ 1.1 I (5) (16) By TMP Nominee, LLC
Stock Purchase Warrant (right to buy) 12/02/2009   (3) Series B Convertible Preferred Stock 3,910 $ 1.1 I (5) (16) By TMP Nominee, LLC
8% Convertible Promissory Note   (4)   (4) Common Stock 2,379 $ (4) I (5) (16) By TMP Nominee, LLC
Series A-1 Convertible Preferred Stock   (1)   (1) Common Stock 4,380 $ (1) I (6) (16) By TMP Associates, L.P.
Series B Convertible Preferred Stock   (1)   (1) Common Stock 786 $ (1) I (6) (16) By TMP Associates, L.P.
Stock Purchase Warrant (right to buy) 12/02/2009   (3) Series B Convertible Preferred Stock 709 $ 1.1 I (6) (16) By TMP Associates, L.P.
Stock Purchase Warrant (right to buy) 12/02/2009   (3) Series B Convertible Preferred Stock 399 $ 1.1 I (6) (16) By TMP Associates, L.P.
Stock Purchase Warrant (right to buy) 12/02/2009   (3) Series B Convertible Preferred Stock 399 $ 1.1 I (6) (16) By TMP Associates, L.P.
Stock Purchase Warrant (right to buy) 12/02/2009   (3) Series B Convertible Preferred Stock 399 $ 1.1 I (6) (16) By TMP Associates, L.P.
8% Convertible Promissory Note   (4)   (4) Common Stock 484 $ (4) I (6) (16) By TMP Associates, L.P.

Reporting Owners

Reporting Owner Name / Address Relationships
Director 10% Owner Officer Other
THOMAS MCNERNEY & PARTNERS LP
60 SOUTH 6TH STREET
SUITE 3620
MINNEAPOLIS, MN 55402
    X    
Thomas, McNerney & Partners, LLC
60 SOUTH 6TH STREET
SUITE 3620
MINNEAPOLIS, MN 55402
    X    
TMP Nominee, LLC
60 SOUTH 6TH STREET
SUITE 3620
MINNEAPOLIS, MN 55402
    X    
TMP ASSOCIATES LP
60 SOUTH 6TH STREET
SUITE 3620
MINNEAPOLIS, MN 55402
    X    
Thomas, McNerney & Partners II L.P.
60 SOUTH 6TH STREET
SUITE 3620
MINNEAPOLIS, MN 55402
    X    
Thomas, McNerney & Partners II, LLC
60 SOUTH 6TH STREET
SUITE 3620
MINNEAPOLIS, MN 55402
    X    
TMP Nominee II, LLC
60 SOUTH 6TH STREET
SUITE 3620
MINNEAPOLIS, MN 55402
    X    
TMP Associates II LP
60 SOUTH 6TH STREET
SUITE 3620
MINNEAPOLIS, MN 55402
    X    
THOMAS JAMES E
60 SOUTH 6TH STREET
SUITE 3620
MINNEAPOLIS, MN 55402
    X    
McNerney Pete
60 SOUTH 6TH STREET
SUITE 3620
MINNEAPOLIS, MN 55402
    X    

Signatures

/s/ James E. Thomas, Manager of Thomas, McNerney & Partners, LLC, the general partner of Thomas, McNerney & Partners, L.P. 11/22/2010
**Signature of Reporting Person Date

/s/ James E. Thomas, Manager of Thomas, McNerney & Partners, LLC 11/22/2010
**Signature of Reporting Person Date

/s/ James E. Thomas, Manager of TMP Nominee, LLC 11/22/2010
**Signature of Reporting Person Date

/s/ James E. Thomas, Manager of Thomas, McNerney & Partners, LLC, the general partner of TMP Associates, L.P. 11/22/2010
**Signature of Reporting Person Date

/s/ James E. Thomas, Manager of Thomas, McNerney & Partners II, LLC, the general partner of Thomas, McNerney & Partners II, L.P. 11/22/2010
**Signature of Reporting Person Date

/s/ James E. Thomas, Manager of Thomas, McNerney & Partners II, LLC 11/22/2010
**Signature of Reporting Person Date

/s/ James E. Thomas, Manager of TMP Nominee II, LLC 11/22/2010
**Signature of Reporting Person Date

/s/ James E. Thomas, Manager of Thomas, McNerney & Partners II, LLC, the general partner of TMP Associates II, L.P. 11/22/2010
**Signature of Reporting Person Date

/s/ James E. Thomas 11/22/2010
**Signature of Reporting Person Date

/s/ Peter H. McNerney 11/22/2010
**Signature of Reporting Person Date

Explanation of Responses:

* If the form is filed by more than one reporting person, see Instruction 5(b)(v).
** Intentional misstatements or omissions of facts constitute Federal Criminal Violations. See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
(1) Each of the Series A-1 Convertible Preferred Stock and the Series B Convertible Preferred Stock has no expiration date, is convertible at any time, in whole or in part, at the election of the holder, and will automatically convert upon the closing of the Issuer's initial public offering at a conversion ratio of one share of Common Stock for every ten shares of Series A-1 Convertible Preferred Stock and one share of Common Stock for every ten shares of Series B Convertible Preferred Stock, as applicable, rounded down to the next whole number, for no additional consideration.
(3) These Warrants (the "Bridge Warrants") were issued on separate dates pursuant to that certain Note and Warrant Purchase Agreement dated as of February 27, 2009, and are exercisable, in whole or in part, for shares of Series B Convertible Preferred Stock of the Issuer as of December 2, 2009. Upon the closing of the Issuer's initial public offering, the Bridge Warrants will become exercisable for Common Stock at a ratio of one share of Common Stock for every ten shares of Series B Convertible Preferred Stock represented thereby, rounded down to the next whole number, at a correspondingly adjusted exercise price of $11.00 per share of Common Stock; provided, however, that because the exercise price of the Bridge Warrants exceeds the initial public offering price of $4.00 per share, the Series B Warrants will not be exercised prior to, and will therefore terminate upon, completion of the initial public offering.
(4) The principle of the Note and accrued interest thereon will automatically convert into shares of Common Stock upon the closing of the Issuer's initial public offering at a conversion price equal to the per share price of the Common Stock sold in the Issuer's initial public offering, which is anticipated to occur on November 29, 2010 at a price of $4.00 per share.
(5) These securities are owned of record by TMP Nominee, LLC ("TMP Nominee"). The managers of TMP Nominee having shared voting and dispositive power over these securities are James E. Thomas and Peter H. McNerney, each of whom disclaims beneficial ownership of such shares except to the extent of their pecuniary interest therein.
(6) These securities are owned of record by TMP Associates, L.P. ("TMP Associates"). TMP LLC is the general partner of TMP Associates and has shared voting and dispositive power of the securities held by TMP Associates, but TMP LLC disclaims beneficial ownership of such securities except to the extent of its pecuniary interest therein. The managers of TMP LLC having shared voting and dispositive power over these securities are James E. Thomas and Peter H. McNerney, each of whom disclaims beneficial ownership of such shares except to the extent of their pecuniary interest therein.
(16) The filing of this statement shall not be deemed an admission that, for the purposes of Section 16 of the Securities Exchange Act of 1934 or otherwise, the Reporting Persons are the beneficial owners of equity securities covered by this statement.
 
Remarks:
Because of the limitations on the number of line-item holdings that can be filed on any one Form 3 through the SEC's EDGAR system, the reporting persons have filed three (3)  Form 3's with respect to Zogenix, Inc. on the date hereof, which, taken together, constitute one Form 3. The Reporting Person named in Box 1 of these three Form 3's is Thomas, McNerney & Partners, L.P.  This Form 3 is filed as Part 2 of 3 parts.

Note: File three copies of this Form, one of which must be manually signed. If space is insufficient, See Instruction 6 for procedure.

Potential persons who are to respond to the collection of information contained in this form are not required to respond unless the form displays a currently valid OMB number.