Ownership Submission
FORM 4
Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).
UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP OF SECURITIES

Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934, Section 17(a) of the Public Utility Holding Company Act of 1935 or Section 30(h) of the Investment Company Act of 1940
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(Print or Type Responses)
1. Name and Address of Reporting Person *
Parker Wayne L
  2. Issuer Name and Ticker or Trading Symbol
PRESSTEK INC /DE/ [PRST]
5. Relationship of Reporting Person(s) to Issuer
(Check all applicable)
_____ Director _____ 10% Owner
__X__ Officer (give title below) _____ Other (specify below)
VP-Corp. Cnt. (Pr. Acct. Off.)
(Last)
(First)
(Middle)
C/O PRESSTEK, INC., 2 GREENWICH OFFICE PARK
3. Date of Earliest Transaction (Month/Day/Year)
09/30/2010
(Street)

GREENWICH, CT 06831
4. If Amendment, Date Original Filed(Month/Day/Year)
6. Individual or Joint/Group Filing(Check Applicable Line)
_X_ Form filed by One Reporting Person
___ Form filed by More than One Reporting Person
(City)
(State)
(Zip)
Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned
1.Title of Security
(Instr. 3)
2. Transaction Date (Month/Day/Year) 2A. Deemed Execution Date, if any (Month/Day/Year) 3. Transaction Code
(Instr. 8)
4. Securities Acquired (A) or Disposed of (D)
(Instr. 3, 4 and 5)
5. Amount of Securities Beneficially Owned Following Reported Transaction(s)
(Instr. 3 and 4)
6. Ownership Form: Direct (D) or Indirect (I)
(Instr. 4)
7. Nature of Indirect Beneficial Ownership
(Instr. 4)
Code V Amount (A) or (D) Price

Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.
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Table II - Derivative Securities Acquired, Disposed of, or Beneficially Owned
(e.g., puts, calls, warrants, options, convertible securities)
1. Title of Derivative Security
(Instr. 3)
2. Conversion or Exercise Price of Derivative Security 3. Transaction Date (Month/Day/Year) 3A. Deemed Execution Date, if any (Month/Day/Year) 4. Transaction Code
(Instr. 8)
5. Number of Derivative Securities Acquired (A) or Disposed of (D)
(Instr. 3, 4, and 5)
6. Date Exercisable and Expiration Date
(Month/Day/Year)
7. Title and Amount of Underlying Securities
(Instr. 3 and 4)
8. Price of Derivative Security
(Instr. 5)
9. Number of Derivative Securities Beneficially Owned Following Reported Transaction(s)
(Instr. 4)
10. Ownership Form of Derivative Security: Direct (D) or Indirect (I)
(Instr. 4)
11. Nature of Indirect Beneficial Ownership
(Instr. 4)
Code V (A) (D) Date Exercisable Expiration Date Title Amount or Number of Shares
Stock Option (right to buy) $ 7.31 09/30/2010   D(1)     10,000   (2) 06/07/2017 Common Stock 10,000 $ 0 10,000 D  
Stock Option (right to buy) $ 2.19 09/30/2010   A(1)   10,000     (2) 06/07/2017 Common Stock 10,000 $ 0 10,000 D  
Stock Option (right to buy) $ 5.03 09/30/2010   D(1)     15,000   (3) 04/21/2018 Common Stock 15,000 $ 0 15,000 D  
Stock Option (right to buy) $ 2.19 09/30/2010   A(1)   15,000     (3) 04/21/2018 Common Stock 15,000 $ 0 15,000 D  

Reporting Owners

Reporting Owner Name / Address Relationships
 Director  10% Owner  Officer  Other
Parker Wayne L
C/O PRESSTEK, INC.
2 GREENWICH OFFICE PARK
GREENWICH, CT 06831
      VP-Corp. Cnt. (Pr. Acct. Off.)  

Signatures

 /s/ James R. Van Horn, Attorney-in-Fact   10/04/2010
**Signature of Reporting Person Date

Explanation of Responses:

* If the form is filed by more than one reporting person, see Instruction 4(b)(v).
** Intentional misstatements or omissions of facts constitute Federal Criminal Violations. See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
(1) The four reported transactions involved amendments of two outstanding options, resulting in the deemed cancellation of the "old" options and the grants of replacement options.
(2) Stock option shares vest 2,500 per year beginning on June 7, 2008 and each year thereafter until fully vested.
(3) Stock option shares vest 25% on each anniversary of the date of grant beginning on April 21, 2008.

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