Schedule 13D
Cusip No. 812578102

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                                  UNITED STATES
                       SECURITIES AND EXCHANGE COMMISSION
                             Washington, D.C. 20549

                                  SCHEDULE 13D
                                 (Rule 13d-101)  

                    Under the Securities Exchange Act of 1934
                                (Amendment No. 1)

                             Seattle Genetics, Inc.
--------------------------------------------------------------------------------
                                (Name of Issuer)

                    Common Stock, par value $0.001 per share
                    ----------------------------------------
                         (Title of Class of Securities)

                                    812578102
                                    ---------
                                 (CUSIP Number)

                               Phillip Isom, Esq.
                              O'Melveny & Myers LLP
                                 7 Times Square
                               New York, NY 10036
                            Telephone: (212) 408-2418
--------------------------------------------------------------------------------
            (Name, Address and Telephone Number of Person Authorized
                     to Receive Notices and Communications)

                               December 31, 2004 
             -------------------------------------------------------
             (Date of Event which Requires Filing of this Statement)

      If the filing person has previously filed a statement on Schedule 13G to
report the acquisition that is the subject of this Schedule 13D, and is filing
this schedule because of Rule 13d-l(e), 13d-l(f) or 13d-l(g), check the
following box |_|

      Note: Schedules filed in paper format shall include a signed original and
five copies of the schedule, including all exhibits. See Rule 13d-7 for other
parties to whom copies are to be sent. The remainder of this cover page shall be
filled out for a reporting person's initial filing on this form with respect to
the subject class of securities, and for any subsequent amendment containing
information which would alter disclosures provided in a prior cover page. The
information required on this cover page shall not be deemed to be "filed" for
the purpose of Section 18 of the Securities Exchange Act of 1934 ("Exchange
Act") or otherwise subject to the liabilities of that section of the Exchange
Act but shall be subject to all other provisions of the Exchange Act (however,
see the Notes)

                                  Page 1 of 28



Schedule 13D
Cusip No. 812578102


--------------------------------------------------------------------------------
1        NAMES OF REPORTING PERSONS
         I.R.S. IDENTIFICATION NOS. OF ABOVE PERSONS (ENTITIES ONLY)

         J.P. Morgan Partners (BHCA), L.P. 
         13-3371826
--------------------------------------------------------------------------------
2        CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP                       
                                                                    (a) |_|
                                                                    (b) |X|
--------------------------------------------------------------------------------
3        SEC USE ONLY
--------------------------------------------------------------------------------
4        SOURCE OF FUNDS
                  WC
--------------------------------------------------------------------------------
5        CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED
         PURSUANT TO ITEMS 2(d) or 2(e)                                 |_|
--------------------------------------------------------------------------------
6        CITIZENSHIP OR PLACE OF ORGANIZATION
                  Delaware
--------------------------------------------------------------------------------
SHARES BENEFICIALLY OWNED    7        SOLE VOTING POWER
 BY EACH REPORTING PERSON             1,083,465 (includes shares of Series A
           WITH              Convertible Preferred Stock and Warrant to Purchase
                             601,925 shares of common stock)
--------------------------------------------------------------------------------
                             8        SHARED VOTING POWER
                                            0
--------------------------------------------------------------------------------
                             9        SOLE DISPOSITIVE POWER
                                      1,083,465 (includes shares of Series A
                             Convertible Preferred Stock and Warrant to Purchase
                             601,925 shares of common stock)

--------------------------------------------------------------------------------
                             10       SHARED DISPOSITIVE POWER
                                            0
--------------------------------------------------------------------------------
11       AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
         1,083,465 (includes shares of Series A Convertible  Preferred Stock and
         Warrant to Purchase 601,925 shares of common stock)
--------------------------------------------------------------------------------
12       CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES
         CERTAIN SHARES(1)                                               |X|
--------------------------------------------------------------------------------
13       PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)
                           11.0 %
--------------------------------------------------------------------------------
14       TYPE OF REPORTING PERSON
                  PN
--------------------------------------------------------------------------------

----------
(1) The Reporting Person above is party to a voting  agreement  contained in the
Investors Rights Agreement  described  herein.  As a result,  the parties to the
Investors Rights Agreement may be deemed to constitute a "group" for purposes of
Section 13(d)(3) of the Securities  Exchange Act of 1934, as amended (the "Act")
with respect to 16,875,000 shares of Common Stock (defined herein), representing
29.6% of the outstanding  voting power of the Issuer. The Reporting Person above
disclaims  beneficial  ownership of any securities  held by any other  Reporting
Person and the filing of this  Statement  on Schedule 13D shall not be deemed an
admission  that the  Reporting  Person  above  and any other  person or  persons
constitute a "group" for  purposes of Section  13(d)(3) of the Act or Rule 13d-5
thereunder.

                                  Page 2 of 28



--------------------------------------------------------------------------------
1        NAMES OF REPORTING PERSONS
         I.R.S. IDENTIFICATION NOS. OF ABOVE PERSONS (ENTITIES ONLY)

         J.P. Morgan Partners Global Investors, L.P. 
         13-4197054
--------------------------------------------------------------------------------
2        CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP
                                                                    (a) |_|
                                                                    (b) |X|
--------------------------------------------------------------------------------
3        SEC USE ONLY
--------------------------------------------------------------------------------
4        SOURCE OF FUNDS
                  WC
--------------------------------------------------------------------------------
5        CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED
         PURSUANT TO ITEMS 2(d) or 2(e)                                 |_|
--------------------------------------------------------------------------------
6        CITIZENSHIP OR PLACE OF ORGANIZATION
                  Delaware
--------------------------------------------------------------------------------
SHARES BENEFICIALLY OWNED     7        SOLE VOTING POWER
 BY EACH REPORTING PERSON              182,558 (includes shares of Series A 
           WITH               Convertible Preferred Stock and Warrant to 
                              purchase 101,421 shares of Common Stock)
                              --------------------------------------------------
                              8        SHARED VOTING POWER
                                            0
                              --------------------------------------------------
                              9        SOLE DISPOSITIVE POWER
                                       182,558 (includes shares of Series A 
                              Convertible Preferred Stock and Warrant to 
                              purchase 101,421 shares of Common Stock)
                              --------------------------------------------------
                              10       SHARED DISPOSITIVE POWER
                                            0
--------------------------------------------------------------------------------
11       AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
                  182,558  (includes  shares of Series A  Convertible  Preferred
         Stock and Warrant to purchase 101,421 shares of Common Stock)
--------------------------------------------------------------------------------
12       CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES
         CERTAIN SHARES(2)                                              |X|
--------------------------------------------------------------------------------
13       PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)
                           1.9%
--------------------------------------------------------------------------------
14       TYPE OF REPORTING PERSON
                  PN
--------------------------------------------------------------------------------

----------
(2) The Reporting Person above is party to a voting  agreement  contained in the
Investors Rights Agreement  described  herein.  As a result,  the parties to the
Investors Rights Agreement may be deemed to constitute a "group" for purposes of
Section 13(d)(3) of the Securities  Exchange Act of 1934, as amended (the "Act")
with respect to 16,875,000 shares of Common Stock (defined herein), representing
29.6% of the outstanding  voting power of the Issuer. The Reporting Person above
disclaims  beneficial  ownership of any securities  held by any other  Reporting
Person and the filing of this  Statement  on Schedule 13D shall not be deemed an
admission  that the  Reporting  Person  above  and any other  person or  persons
constitute a "group" for  purposes of Section  13(d)(3) of the Act or Rule 13d-5
thereunder.

                                  Page 3 of 28



--------------------------------------------------------------------------------
1        NAMES OF REPORTING PERSONS
         I.R.S. IDENTIFICATION NOS. OF ABOVE PERSONS (ENTITIES ONLY)

         J.P. Morgan Partners Global Investors A, L.P. 
         26-0032493
--------------------------------------------------------------------------------
2        CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP
                                                                    (a) |_|
                                                                    (b) |X|
--------------------------------------------------------------------------------
3        SEC USE ONLY
--------------------------------------------------------------------------------
4        SOURCE OF FUNDS
                  WC
--------------------------------------------------------------------------------
5        CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED
         PURSUANT TO ITEMS 2(d) or 2(e)                                 |_|
--------------------------------------------------------------------------------
6        CITIZENSHIP OR PLACE OF ORGANIZATION
                  Delaware
--------------------------------------------------------------------------------
SHARES BENEFICIALLY OWNED    7        SOLE VOTING POWER
 BY EACH REPORTING PERSON             24,887 (includes shares of Series A 
           WITH              Convertible Preferred Stock and warrant to purchase
                              13,826 shares of Common Stock)
                             ---------------------------------------------------
                             8        SHARED VOTING POWER
                                            0
                             ---------------------------------------------------
                             9        SOLE DISPOSITIVE POWER
                                      24,887 (includes shares of Series A 
                             Convertible Preferred Stock and warrant to purchase
                              13,826 shares of Common Stock)
                             ---------------------------------------------------
                             10       SHARED DISPOSITIVE POWER
                                            0
--------------------------------------------------------------------------------
11       AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
         24,887  (includes  shares of Series A Convertible  Preferred  Stock and
         warrant to purchase 13,826 shares of Common Stock)
--------------------------------------------------------------------------------
12       CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES
         CERTAIN SHARES(3)                                              |X|
--------------------------------------------------------------------------------
13       PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)
                           0.3 %
--------------------------------------------------------------------------------
14       TYPE OF REPORTING PERSON
                  PN
--------------------------------------------------------------------------------

----------
(3) The Reporting Person above is party to a voting  agreement  contained in the
Investors Rights Agreement  described  herein.  As a result,  the parties to the
Investors Rights Agreement may be deemed to constitute a "group" for purposes of
Section 13(d)(3) of the Securities  Exchange Act of 1934, as amended (the "Act")
with respect to 16,875,000 shares of Common Stock (defined herein), representing
29.6% of the outstanding  voting power of the Issuer. The Reporting Person above
disclaims  beneficial  ownership of any securities  held by any other  Reporting
Person and the filing of this  Statement  on Schedule 13D shall not be deemed an
admission  that the  Reporting  Person  above  and any other  person or  persons
constitute a "group" for  purposes of Section  13(d)(3) of the Act or Rule 13d-5
thereunder.

                                  Page 4 of 28



--------------------------------------------------------------------------------
1        NAMES OF REPORTING PERSONS
         I.R.S. IDENTIFICATION NOS. OF ABOVE PERSONS (ENTITIES ONLY)

         J.P. Morgan Partners Global Investors (Cayman), L.P. 
         13-4197057
--------------------------------------------------------------------------------
2        CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP
                                                                    (a) |_|
                                                                    (b) |X|
--------------------------------------------------------------------------------
3        SEC USE ONLY
--------------------------------------------------------------------------------
4        SOURCE OF FUNDS
                  WC
--------------------------------------------------------------------------------
5        CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED
         PURSUANT TO ITEMS 2(d) or 2(e)                                 |_|
--------------------------------------------------------------------------------
6        CITIZENSHIP OR PLACE OF ORGANIZATION
                  Cayman Islands
--------------------------------------------------------------------------------
SHARES BENEFICIALLY OWNED    7        SOLE VOTING POWER
 BY EACH REPORTING PERSON             92,660 (includes shares of Series A 
           WITH              Convertible Preferred Stock and warrant to purchase
                              51,478 shares of Common Stock)
                             ---------------------------------------------------
                             8        SHARED VOTING POWER
                                            0
                             ---------------------------------------------------
                             9        SOLE DISPOSITIVE POWER
                                      92,660 (includes shares of Series A 
                             Convertible Preferred Stock and warrant to purchase
                             51,478 shares of Common Stock)
                             ---------------------------------------------------
                             10       SHARED DISPOSITIVE POWER
                                            0
--------------------------------------------------------------------------------
11       AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
         92,660  (includes  shares of Series A Convertible  Preferred  Stock and
         warrant to purchase 51,478 shares of Common Stock)
--------------------------------------------------------------------------------
12       CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES
         CERTAIN SHARES(4)                                             |X|
--------------------------------------------------------------------------------
13       PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)
                             .9 %
--------------------------------------------------------------------------------
14       TYPE OF REPORTING PERSON
                  PN
--------------------------------------------------------------------------------

----------
(4) The Reporting Person above is party to a voting  agreement  contained in the
Investors Rights Agreement  described  herein.  As a result,  the parties to the
Investors Rights Agreement may be deemed to constitute a "group" for purposes of
Section 13(d)(3) of the Securities  Exchange Act of 1934, as amended (the "Act")
with respect to 16,875,000 shares of Common Stock (defined herein), representing
29.6% of the outstanding  voting power of the Issuer. The Reporting Person above
disclaims  beneficial  ownership of any securities  held by any other  Reporting
Person and the filing of this  Statement  on Schedule 13D shall not be deemed an
admission  that the  Reporting  Person  above  and any other  person or  persons
constitute a "group" for  purposes of Section  13(d)(3) of the Act or Rule 13d-5
thereunder.

                                  Page 5 of 28



--------------------------------------------------------------------------------
1        NAMES OF REPORTING PERSONS
         I.R.S. IDENTIFICATION NOS. OF ABOVE PERSONS (ENTITIES ONLY)

         J.P. Morgan Partners Global Investors (Cayman) II, L.P. 
         26-0005546
--------------------------------------------------------------------------------
2        CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP
                                                                    (a) |_|
                                                                    (b) |X|
--------------------------------------------------------------------------------
3        SEC USE ONLY
--------------------------------------------------------------------------------
4        SOURCE OF FUNDS
                  WC
--------------------------------------------------------------------------------
5        CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED
         PURSUANT TO ITEMS 2(d) or 2(e)                                 |_|
--------------------------------------------------------------------------------
6        CITIZENSHIP OR PLACE OF ORGANIZATION
                  Cayman Islands
--------------------------------------------------------------------------------
SHARES BENEFICIALLY OWNED    7        SOLE VOTING POWER
 BY EACH REPORTING PERSON             10,325 (includes shares of Series A 
           WITH              Convertible Preferred Stock and warrant to purchase
                              5,736 shares of Common Stock)
                             ---------------------------------------------------
                             8        SHARED VOTING POWER
                                                    0
                             ---------------------------------------------------
                             9        SOLE DISPOSITIVE POWER
                                      10,325 (includes shares of Series A 
                             Convertible Preferred Stock and warrant to purchase
                              5,736 shares of Common Stock)
                             ---------------------------------------------------
                             10       SHARED DISPOSITIVE POWER
                                                    0
--------------------------------------------------------------------------------
11       AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
         10,325  (includes  shares  of Series A  Convertible  Preferred Stock 
         and warrant to purchase 5,736 shares of Common Stock)
--------------------------------------------------------------------------------
12       CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES
         CERTAIN SHARES(5)                                              |X|
--------------------------------------------------------------------------------
13       PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)
                         0.1 %
--------------------------------------------------------------------------------
14       TYPE OF REPORTING PERSON
                  PN
--------------------------------------------------------------------------------

----------
(5) The Reporting Person above is party to a voting  agreement  contained in the
Investors Rights Agreement  described  herein.  As a result,  the parties to the
Investors Rights Agreement may be deemed to constitute a "group" for purposes of
Section 13(d)(3) of the Securities  Exchange Act of 1934, as amended (the "Act")
with respect to 16,875,000 shares of Common Stock (defined herein), representing
29.6% of the outstanding  voting power of the Issuer. The Reporting Person above
disclaims  beneficial  ownership of any securities  held by any other  Reporting
Person and the filing of this  Statement  on Schedule 13D shall not be deemed an
admission  that the  Reporting  Person  above  and any other  person or  persons
constitute a "group" for  purposes of Section  13(d)(3) of the Act or Rule 13d-5
thereunder

                                  Page 6 of 28



--------------------------------------------------------------------------------
1        NAMES OF REPORTING PERSONS
         I.R.S. IDENTIFICATION NOS. OF ABOVE PERSONS (ENTITIES ONLY)

         J.P. Morgan Partners Global Investors (Selldown), L.P. 
         56-2489868
--------------------------------------------------------------------------------
2        CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP
                                                                    (a) |_|
                                                                    (b) |X|
--------------------------------------------------------------------------------
3        SEC USE ONLY
--------------------------------------------------------------------------------
4        SOURCE OF FUNDS
                  WC
--------------------------------------------------------------------------------
5        CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED
         PURSUANT TO ITEMS 2(d) or 2(e)                                 |_|
--------------------------------------------------------------------------------
6        CITIZENSHIP OR PLACE OF ORGANIZATION
                  Cayman Islands
--------------------------------------------------------------------------------
SHARES BENEFICIALLY OWNED    7        SOLE VOTING POWER
 BY EACH REPORTING PERSON             68,605 (includes shares of Series A 
           WITH              Convertible Preferred Stock and warrant to purchase
                              38,114 shares of Common Stock)
                             ---------------------------------------------------
                             8        SHARED VOTING POWER
                                           0
                             ---------------------------------------------------
                             9        SOLE DISPOSITIVE POWER
                                      68,605 (includes shares of Series A 
                             Convertible Preferred Stock and warrant to purchase
                             38,114 shares of Common Stock)
                             ---------------------------------------------------
                             10       SHARED DISPOSITIVE POWER
                                           0
--------------------------------------------------------------------------------
11       AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
         68,605  (includes  shares  of Series A  Convertible  Preferred Stock 
         and warrant to purchase 38,114 shares of Common Stock)
--------------------------------------------------------------------------------
12       CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES
         CERTAIN SHARES(6)                                             |X|
--------------------------------------------------------------------------------
13       PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)
                           0.7 %
--------------------------------------------------------------------------------
14       TYPE OF REPORTING PERSON
                  PN
--------------------------------------------------------------------------------

---------- 
(6) The Reporting Person above is party to a voting  agreement  contained in the
Investors Rights Agreement  described  herein.  As a result,  the parties to the
Investors Rights Agreement may be deemed to constitute a "group" for purposes of
Section 13(d)(3) of the Securities  Exchange Act of 1934, as amended (the "Act")
with respect to 16,875,000 shares of Common Stock (defined herein), representing
29.6% of the outstanding  voting power of the Issuer. The Reporting Person above
disclaims  beneficial  ownership of any securities  held by any other  Reporting
Person and the filing of this  Statement  on Schedule 13D shall not be deemed an
admission  that the  Reporting  Person  above  and any other  person or  persons
constitute a "group" for  purposes of Section  13(d)(3) of the Act or Rule 13d-5
thereunder.


                                  Page 7 of 28



--------------------------------------------------------------------------------
     1       NAMES OF REPORTING PERSONS I.R.S. IDENTIFICATION NOS. OF ABOVE 
             PERSONS

                      Julian C. Baker
--------------------------------------------------------------------------------
     2       CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP (See Instructions)
                                                                    (a) |_|
                                                                    (b) |X|
--------------------------------------------------------------------------------
     3       SEC USE ONLY
--------------------------------------------------------------------------------
             SOURCE OF FUNDS (See Instructions)
     4
                      WC
--------------------------------------------------------------------------------
     5       CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED PURSUANT 
             TO ITEMS 2(d) OR 2(e)                                      |_| 
--------------------------------------------------------------------------------
     6       CITIZENSHIP OR PLACE OF ORGANIZATION

             United States
--------------------------------------------------------------------------------
NUMBER OF SHARES                               SOLE VOTING POWER
BENEFICIALLY OWNED BY EACH               7
REPORTING PERSON                                         -0-
WITH
                                     -------------------------------------------
                                                SHARED VOTING POWER
                                         8
                                                        7,312,500
                                     -------------------------------------------
                                                SOLE DISPOSITIVE POWER
                                         9
                                                         -0-
                                     -------------------------------------------
                                                SHARED DISPOSITIVE POWER
                                        10
                                                        7,312,500
--------------------------------------------------------------------------------
    11       AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

                      7,312,500
--------------------------------------------------------------------------------
    12       CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN 
             SHARES (See Instructions)                                  |X|
--------------------------------------------------------------------------------
    13       PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)

                      15.4%
--------------------------------------------------------------------------------
             TYPE OF REPORTING PERSON (See Instructions)
    14
                      IN
--------------------------------------------------------------------------------


                                  Page 8 of 28



--------------------------------------------------------------------------------
     1       NAMES OF REPORTING PERSONS I.R.S. IDENTIFICATION NOS. OF ABOVE 
             PERSONS

                      Felix J. Baker
--------------------------------------------------------------------------------
     2       CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP (See Instructions)
                                                                    (a) |_|
                                                                    (b) |X|
--------------------------------------------------------------------------------
     3       SEC USE ONLY
--------------------------------------------------------------------------------
             SOURCE OF FUNDS (See Instructions)
     4
                      WC
--------------------------------------------------------------------------------
     5       CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED PURSUANT 
             TO ITEMS 2(d) OR 2(e)                                      |_| 
--------------------------------------------------------------------------------
     6       CITIZENSHIP OR PLACE OF ORGANIZATION

             United States
--------------------------------------------------------------------------------
NUMBER OF SHARES                        7      SOLE VOTING POWER
BENEFICIALLY OWNED BY 
EACH REPORTING                                           -0-  
PERSON WITH                                            
                                     -------------------------------------------
                                        8      SHARED VOTING POWER
                                     
                                                        7,312,500
                                     -------------------------------------------
                                               SOLE DISPOSITIVE POWER
                                        9
                                                          -0-
                                     -------------------------------------------
                                               SHARED DISPOSITIVE POWER
                                        10
                                                        7,312,500
--------------------------------------------------------------------------------
    11       AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

                      7,312,500
--------------------------------------------------------------------------------
    12       CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN 
             SHARES (See Instructions)                                  |X|
--------------------------------------------------------------------------------
    13       PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)

                         15.4%
--------------------------------------------------------------------------------
             TYPE OF REPORTING PERSON (See Instructions)
    14
                      IN
--------------------------------------------------------------------------------


                                  Page 9 of 28



--------------------------------------------------------------------------------
1        NAMES OF REPORTING PERSONS
         I.R.S. IDENTIFICATION NOS. OF ABOVE PERSONS (ENTITIES ONLY)

            Delphi Ventures VI, L.P.
            42-1561726
--------------------------------------------------------------------------------
2        CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP
                                                                    (a) |_|
                                                                    (b) |X|
--------------------------------------------------------------------------------
3        SEC USE ONLY
--------------------------------------------------------------------------------
4        SOURCE OF FUNDS
                  WC
--------------------------------------------------------------------------------
5        CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED
         PURSUANT TO ITEMS 2(d) or 2(e)                                 |_|
--------------------------------------------------------------------------------
6        CITIZENSHIP OR PLACE OF ORGANIZATION
                  Delaware
--------------------------------------------------------------------------------
SHARES BENEFICIALLY OWNED BY EACH   7          SOLE VOTING POWER
      REPORTING PERSON WITH                              0
--------------------------------------------------------------------------------
                                    8          SHARED VOTING POWER              
                                               2,227,725 (includes 1,980,200 
                                               shares of Common Stock issuable
                                               upon conversion of the Series A 
                                               Convertible Preferred Stock and
                                               247,525 shares of Common Stock 
                                               issuable upon exercise of the
                                               Warrants)
                                    -------------------------------------------
                                    9          SOLE DISPOSITIVE POWER
                                                        0
                                    -------------------------------------------
                                    10         SHARED DISPOSITIVE POWER
                                               2,227,725 (includes 1,980,200 
                                               shares of Common Stock issuable
                                               upon conversion of the Series A 
                                               Convertible Preferred Stock and
                                               247,525 shares of Common Stock 
                                               issuable upon exercise of the
                                               Warrants)
--------------------------------------------------------------------------------
11       AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
         2,227,725  (includes  1,980,200  shares of Common Stock  issuable  upon
         conversion  of the Series A  Convertible  Preferred  Stock and  247,525
         shares of Common Stock issuable upon exercise of the Warrants)
--------------------------------------------------------------------------------
12       CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES
         CERTAIN SHARES7                                                |X|
--------------------------------------------------------------------------------
13       PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)
                           5.3 %
--------------------------------------------------------------------------------
14       TYPE OF REPORTING PERSON
                  PN
--------------------------------------------------------------------------------

----------
(7) The Reporting Person above is party to a voting  agreement  contained in the
Investors Rights Agreement  described  herein.  As a result,  the parties to the
Investors Rights Agreement may be deemed to constitute a "group" for purposes of
Section 13(d)(3) of the Securities  Exchange Act of 1934, as amended (the "Act")
with respect to 16,875,000 shares of Common Stock (defined herein), representing
29.6% of the outstanding  voting power of the Issuer. The Reporting Person above
disclaims  beneficial  ownership of any securities  held by any other  Reporting
Person and the filing of this  Statement  on Schedule 13D shall not be deemed an
admission  that the  Reporting  Person  above  and any other  person or  persons
constitute a "group" for  purposes of Section  13(d)(3) of the Act or Rule 13d-5
thereunder.


                                  Page 10 of 28



--------------------------------------------------------------------------------
1        NAMES OF REPORTING PERSONS
         I.R.S. IDENTIFICATION NOS. OF ABOVE PERSONS (ENTITIES ONLY)

            Delphi BioInvestments VI, L.P.
            04-3760672
--------------------------------------------------------------------------------
2        CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP
                                                                    (a) |_|
                                                                    (b) |X|
--------------------------------------------------------------------------------
3        SEC USE ONLY
--------------------------------------------------------------------------------
4        SOURCE OF FUNDS
                  WC
--------------------------------------------------------------------------------
5        CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED
         PURSUANT TO ITEMS 2(d) or 2(e)                                 |_|
--------------------------------------------------------------------------------
6        CITIZENSHIP OR PLACE OF ORGANIZATION
                  Delaware
--------------------------------------------------------------------------------
  SHARES BENEFICIALLY OWNED          7        SOLE VOTING POWER
BY EACH REPORTING PERSON WITH                           0
--------------------------------------------------------------------------------
                                     8        SHARED VOTING POWER               
                                              22,275    (includes   19,800   
                                              shares   of   Common   Stock   
                                              issuable upon  conversion of   
                                              the  Series  A   Convertible   
                                              Preferred  Stock  and  2,475   
                                              shares   of   Common   Stock   
                                              issuable  upon  exercise  of   
                                              the Warrants)                  
                                    --------------------------------------------
                                     9        SOLE DISPOSITIVE POWER
                                                        0
                                    --------------------------------------------
                                    10        SHARED DISPOSITIVE POWER
                                              22,275    (includes   19,800      
                                              shares   of   Common   Stock      
                                              issuable upon  conversion of      
                                              the  Series  A   Convertible      
                                              Preferred  Stock  and  2,475      
                                              shares   of   Common   Stock      
                                              issuable  upon  exercise  of      
                                              the Warrants)                     
--------------------------------------------------------------------------------
11       AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
         22,275 (includes 19,800 shares of Common Stock issuable upon conversion
         of the Series A Convertible  Preferred Stock and 2,475 shares of Common
         Stock issuable upon exercise of the Warrants)
--------------------------------------------------------------------------------
12       CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES
         CERTAIN SHARES(8)                                              |X|
--------------------------------------------------------------------------------
13       PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)
                           0 %
--------------------------------------------------------------------------------
14       TYPE OF REPORTING PERSON
                  PN
--------------------------------------------------------------------------------

----------
(8) The Reporting Person above is party to a voting  agreement  contained in the
Investors Rights Agreement  described  herein.  As a result,  the parties to the
Investors Rights Agreement may be deemed to constitute a "group" for purposes of
Section 13(d)(3) of the Securities  Exchange Act of 1934, as amended (the "Act")
with respect to 16,875,000 shares of Common Stock (defined herein), representing
29.6% of the outstanding  voting power of the Issuer. The Reporting Person above
disclaims  beneficial  ownership of any securities  held by any other  Reporting
Person and the filing of this  Statement  on Schedule 13D shall not be deemed an
admission  that the  Reporting  Person  above  and any other  person or  persons
constitute a "group" for  purposes of Section  13(d)(3) of the Act or Rule 13d-5
thereunder.


                                  Page 11 of 28



Schedule 13D
Cusip No. 812578102

--------------------------------------------------------------------------------
1        NAMES OF REPORTING PERSONS
         I.R.S. IDENTIFICATION NOS. OF ABOVE PERSONS (ENTITIES ONLY)

            Delphi Management Partners VI, L.L.C.
--------------------------------------------------------------------------------
2        CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP
                                                                    (a) |_|
                                                                    (b) |X|
--------------------------------------------------------------------------------
3        SEC USE ONLY
--------------------------------------------------------------------------------
4        SOURCE OF FUNDS
                  WC
--------------------------------------------------------------------------------
5        CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED
         PURSUANT TO ITEMS 2(d) or 2(e)                                 |_|
--------------------------------------------------------------------------------
6        CITIZENSHIP OR PLACE OF ORGANIZATION
                  Delaware
--------------------------------------------------------------------------------
    SHARES BENEFICIALLY OWNED BY EACH      7        SOLE VOTING POWER
          REPORTING PERSON WITH                                       0
--------------------------------------------------------------------------------
                                           8        SHARED VOTING POWER         
                                                    2,250,000          (includes
                                                    2,000,000  shares  of Common
                                                    Stock      issuable     upon
                                                    conversion  of the  Series A
                                                    Convertible  Preferred Stock
                                                    and 250,000 shares of Common
                                                    Stock issuable upon exercise
                                                    of the Warrants)
                                           -------------------------------------
                                           9        SOLE DISPOSITIVE POWER
                                                                      0
                                           -------------------------------------
                                           10       SHARED DISPOSITIVE POWER
                                                    2,250,000          (includes
                                                    2,000,000  shares  of Common
                                                    Stock      issuable     upon
                                                    conversion  of the  Series A
                                                    Convertible  Preferred Stock
                                                    and 250,000 shares of Common
                                                    Stock issuable upon exercise
                                                    of the Warrants)
--------------------------------------------------------------------------------
11       AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
         2,250,000 (includes 2,000,000 shares of Common Stock issuable upon 
         conversion of the Series  A Convertible Preferred Stock and 250,000 
         shares of Common Stock issuable upon exercise of the Warrants)
--------------------------------------------------------------------------------
12       CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES
         CERTAIN SHARES(9)                                              |X|
--------------------------------------------------------------------------------
13       PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)
                          5.3%
--------------------------------------------------------------------------------
14       TYPE OF REPORTING PERSON
                  OO
--------------------------------------------------------------------------------

----------
(9) The Reporting Person above is party to a voting  agreement  contained in the
Investors Rights Agreement  described  herein.  As a result,  the parties to the
Investors Rights Agreement may be deemed to constitute a "group" for purposes of
Section 13(d)(3) of the Securities  Exchange Act of 1934, as amended (the "Act")
with respect to 16,875,000 shares of Common Stock (defined herein), representing
29.6% of the outstanding  voting power of the Issuer. The Reporting Person above
disclaims  beneficial  ownership of any securities  held by any other  Reporting
Person and the filing of this  Statement  on Schedule 13D shall not be deemed an
admission  that the  Reporting  Person  above  and any other  person or  persons
constitute a "group" for  purposes of Section  13(d)(3) of the Act or Rule 13d-5
thereunder.

                                  Page 12 of 28




Schedule 13D
Cusip No. 812578102

PRELIMINARY  STATEMENT:  This  Schedule  13D is being  amended  to  reflect  and
transfer  of Series A  Convertible  Preferred  Stock and  Warrants  representing
68,605 shares of the Issuer's Common Stock by JPMP (BHCA) to JPMP Selldown (each
hereinafter  defined) and a change in the  executive  officer's and directors of
the controlling persons of the JPMP Reporting Persons.

Item 1.     Security and Issuer.

            The  class of  equity  securities  to  which  this  statement  (this
            "Statement") relates is the Common Stock, par value $0.001 per share
            (the  "Common  Stock")  of  Seattle   Genetics,   Inc.,  a  Delaware
            corporation  (the  "Issuer" or  "Company").  The Issuer's  principal
            executive offices are located at 21823 -- 30th Drive S.E.,  Bothell,
            WA 98021.

Item 2.     Identity and Background.

            JPMP Reporting Persons

            This Statement is being filed by: (i) J.P. Morgan  Partners  (BHCA),
            L.P.,  a limited  partnership  organized  under the laws of Delaware
            ("JPMP (BHCA)"), whose principal office is located at 1221 Avenue of
            the Americas,  New York, NY 10020,  (ii) J.P. Morgan Partners Global
            Investors,  L.P., a limited partnership  organized under the laws of
            Delaware ("JPMP  Global"),  whose principal office is located at the
            same  address as JPMP  (BHCA),  (iii) J.P.  Morgan  Partners  Global
            Investors A, L.P., a limited partnership organized under the laws of
            Delaware ("JPMP Global A"), whose principal office is located at the
            same  address  as JPMP  (BHCA),  (iv) J.P.  Morgan  Partners  Global
            Investors (Cayman),  L.P., a limited partnership organized under the
            laws of the Cayman Islands ("JPMP  Cayman"),  whose principal office
            is  located  at the same  address as JPMP  (BHCA),  (v) J.P.  Morgan
            Partners Global  Investors  (Cayman) II, L.P. a limited  partnership
            organized  under the laws of the Cayman  Islands ("JPMP Cayman II"),
            whose  principal  address  is  located  at the same  address as JPMP
            (BHCA) and (vi) J.P. Morgan Partners  Global  Investors  (Selldown),
            L.P.,  a  Delaware   Limited   Partnership   ("JPMP   Selldown"  and
            collectively with JPMP (BHCA),  JPMP Global,  JPMP Global A and JPMP
            Cayman,  the "JPMP Reporting  Persons"),  whose principal  office is
            located at the same address as JPMP (BHCA).

            JPMP (BHCA) is engaged in the venture  capital,  private  equity and
            leveraged  buyout  business.  The general  partner of JPMP (BHCA) is
            JPMP Master  Fund  Manager,  L.P.,  a Delaware  limited  partnership
            ("JPMP Master Fund"),  whose principal business office is located at
            the same  address as JPMP (BHCA),  and is also engaged  directly and
            indirectly  (through  affiliates)  in the venture  capital,  private
            equity and leveraged buyout business.

            JPMP  Global,  JPMP Global A, JPMP  Cayman,  JPMP Cayman II and JPMP
            Selldown (collectively, the "Global Fund Entities") are also engaged
            in  the  venture  capital,   private  equity  and  leveraged  buyout
            business. The general partner of each of the Global Fund Entities is
            J.P.

                                  Page 13 of 28



            Morgan  Partners  Global   Investors,   L.P.,  a  Delaware   limited
            partnership ("JPMP Investors"), whose principal place of business is
            located  at the same  address  as JPMP  (BHCA).  JPMP  Investors  is
            engaged  indirectly  in the  venture  capital,  private  equity  and
            leveraged  buyout  business as general partner of each of the Global
            Fund Entities.

            The general  partner of each of JPMP Master Fund and JPMP  Investors
            is  JPMP  Capital  Corp.,  a New  York  corporation  ("JPMP  Capital
            Corp."),  whose  principal  business  office is  located at the same
            address as JPMP (BHCA),  and is also engaged directly and indirectly
            (through  affiliates)  in the venture  capital,  private  equity and
            leveraged  buyout  business.  Set  forth in  Schedule  A hereto  and
            incorporated herein by reference are the names,  business addresses,
            principal  occupations and employments of each executive officer and
            director of JPMP Capital Corp.

            JPMP Capital Corp. is a wholly owned  subsidiary of JPMorgan Chase &
            Co.,  a Delaware  Corporation  ("JPMorgan  Chase")  which is engaged
            (primarily through  subsidiaries) in the commercial banking business
            with its principal  office located at 270 Park Avenue,  New York, NY
            10018.  Set forth in  Schedule B hereto and  incorporated  herein by
            reference are the names,  business addresses,  principal occupations
            and  employments of each executive  officer and director of JPMorgan
            Chase.

            Baker Reporting Persons

            This  Statement is also being filed by: (i) Julian C. Baker and (ii)
            Felix  J.  Baker,  each of whom is a  United  States  citizen  whose
            principal  office is located at 667  Madison  Avenue,  New York,  NY
            10021 (collectively, the "Baker Reporting Persons"). Set forth below
            is certain information with respect to the Baker Reporting Persons:

            Name                  Present Principal Occupation

            Julian C. Baker       Managing Member, Baker Bros. Advisors, LLC 
                                 (an entity engaged in investment activities)
                                 
            Felix J. Baker        Managing Member, Baker Bros. Advisors, LLC 
                                 (an entity engaged in investment activities)
                                  
            Delphi Reporting Persons

            This Statement is also being filed by: (i) Delphi Ventures VI, L.P.,
            a limited partnership  organized under the laws of Delaware ("Delphi
            Ventures"),  whose  principal  office is  located  at 3000 Sand Hill
            Road,  Building  1, Suite 135,  Menlo  Park,  CA 94025,  (ii) Delphi
            BioInvestments VI, L.P., a limited  partnership  organized under the
            laws of Delaware ("Delphi  BioInvestments"),  whose principal office
            is located at the same address as Delphi Ventures,  and (iii) Delphi
            Management Partners VI, L.L.C., a Delaware limited liability company
            ("Delphi  Management",  and together with Delphi Ventures and Delphi
            BioInvestments,  the "Delphi  Reporting  Persons")  whose  principal
            office is located at the same address as Delphi Ventures.

                                  Page 14 of 28



            The Delphi  Reporting  Persons are  engaged in the  venture  capital
            business.  The general partner of each of Delphi Ventures and Delphi
            BioInvestments  is  Delphi  Management.  Delphi  Management  is also
            engaged  indirectly  (through  affiliates)  in the  venture  capital
            business.  Set forth in Schedule C hereto and incorporated herein by
            reference are the names,  business addresses,  principal occupations
            and employments of each managing member of Delphi Management.

            The Delphi  Reporting  Persons,  the JPMP Reporting  Persons and the
            Baker Reporting  Persons are collectively  referred to herein as the
            "Reporting Persons".

            During the last five years,  none of the Reporting Persons have been
            convicted in any criminal  proceeding  (excluding traffic violations
            or similar  misdemeanors) or have been a party to a civil proceeding
            of a  judicial  or  administrative  body of  competent  jurisdiction
            resulting  in their  being  subject to a  judgment,  decree or final
            order  enjoining  future  violations of, or prohibiting or mandating
            activities  subject to, federal or state securities laws, or finding
            any violations with respect to such laws.

Item 3.     Source and Amount of Funds or Other Consideration.

            JPMP Reporting Persons:

            The funds  provided by JPMP (BHCA) and the Global Fund  Entities for
            the  purchase  of the  securities  reported  in  Item 5  below  were
            obtained from the contributed  capital and available working capital
            of JPMP (BHCA) and the Global Fund  Entities,  which  includes funds
            that are held available for such purpose.

            Baker Reporting Persons:

            The funds used by the limited  partnerships  controlled by Julian C.
            Baker and Felix J. Baker to purchase the securities reported in Item
            5 below were  provided from the  available  working  capital of such
            limited partnerships.

            Delphi Reporting Persons:

            The funds provided by Delphi Ventures and Delphi  BioInvestments for
            the  purchase  of the  securities  reported  in  Item 5  below  were
            obtained from the contributed  capital and available working capital
            of Delphi  Ventures and Delphi  BioInvestments  respectively,  which
            includes funds that are held available for such purpose.

                                  Page 15 of 28



Item 4.     Purpose of Transactions.

            The securities referred to in Item 5 below were acquired pursuant to
            the Securities Purchase Agreement referred to in Item 6 below solely
            for investment purposes.

            The transactions described in Item 6 below are incorporated in their
            entirety herein by reference. 

            Subject  to the  rights of the  Reporting  Persons  set forth in the
            Securities  Purchase  Agreement and the Investors  Rights  Agreement
            referred  to in Item 6 below,  except  as set  forth in this Item 4,
            none of the JPMP Reporting Persons,  the Baker Reporting Persons, or
            the Delphi  Reporting  Persons have a present plan or proposal  that
            relates  to or  would  result  in any of the  actions  specified  in
            clauses (a) through (j) of Item 4 of Schedule 13D. However,  each of
            the JPMP  Reporting  Persons,  the Baker  Reporting  Persons and the
            Delphi   Reporting   Persons   reserves  the  right  to  propose  or
            participate in future  transactions  which may result in one or more
            of such  actions,  including  but not limited  to, an  extraordinary
            corporate   transaction,   such  as  a  merger,   reorganization  or
            liquidation,  sale of a  material  amount of assets of the Issuer or
            its subsidiaries,  or other transactions which might have the effect
            of causing the  Issuer's  Common  Stock to cease to be listed on the
            NASDAQ  National Market System or causing the Common Stock to become
            eligible for termination of registration, under section 12(g) of the
            Securities Exchange Act of 1934, as amended (the "Act").

Item 5.     Interest in Securities of the Issuer.

            The percentages of outstanding shares of the Issuer reported in this
            Item 5 are based on 41,952,000 shares of Common Stock outstanding as
            of December 31, 2004.

            JPMP Reporting Persons

            JPMP  (BHCA)  beneficially  owns  1,083,465  shares of the  Issuer's
            Common Stock,  which  represents 11.0% of the Issuer's Common Stock.
            JPMP Global  beneficially  owns 82,558 shares of the Issuer's Common
            Stock,  which  represents  1.9% of the Issuer's  Common Stock.  JPMP
            Global A  beneficially  owns 24,887  shares of the  Issuer's  Common
            Stock,  which  represents  0.3% of the Issuer's  Common Stock.  JPMP
            Cayman beneficially owns 92,660 shares of the Issuer's Common Stock,
            which  represents .9% of the Issuer's  Common Stock.  JPMP Cayman II
            beneficially owns 10,325 shares of the Issuer's Common Stock,  which
            represents  0.1%  of  the  Issuer's  Common  Stock.   JPMP  Selldown
            beneficially owns 68,605 shares of the Issuer's Common Stock,  which
            represents .07% the Issuer's Common Stock.

            JPMP Master  Fund,  as the General  Partner of JPMP  (BHCA),  may be
            deemed to  beneficially  own the shares  beneficially  owned by JPMP
            (BHCA).

                                  Page 16 of 28



            JPMP  Investors,  as the General  Partner of each of the Global Fund
            Entities,  may be deemed to beneficially own the shares beneficially
            owned by each of the Global Fund Entities.

            JPMP Capital  Corp.,  as the General  Partner of each of JPMP Master
            Fund and JPMP  Investors,  may be  deemed  to  beneficially  own the
            shares beneficially owned by JPMP (BHCA) and each of the Global Fund
            Entities.

           JPMP Capital Corp. is a wholly owned subsidiary of JPMorgan Chase & 
           Co., a publicly traded company.

           The foregoing  shall not be an admission that JPMP Master Fund,  JPMP
           Investors  or JPMP Capital  Corp.  are the  beneficial  owners of the
           shares held by JPMP (BHCA) and/or the Global Fund Entities.

           Baker Reporting Persons:

           Set forth in the  table  below is the  aggregate  number of shares of
           Common Stock  beneficially owned as of the date hereof by each of the
           limited  partnerships  controlled  by the  Baker  Reporting  Persons,
           together with the  percentage of  outstanding  shares of Common Stock
           that such ownership represents based upon 40,196,299 shares of Common
           Stock  outstanding as of March 22, 2004, as reported by the Issuer in
           its most recent  Schedule 14A filed on April 16,  2004,  in each case
           taking into  account the shares of Common  Stock that can be acquired
           upon conversion of Series A Convertible  Preferred Stock and exercise
           of the Warrants to purchase shares of Common Stock:



                                                                     Percent of Class
                             Name                  Number of Shares       Outstanding
            --------------------------------       ----------------  ----------------
                                                                            
            Baker/Tisch Investments, L.P.               446,063                  0.9%
            Baker Bros. Investments, L.P.               301,275                  0.6%
            Baker Bros. Investments II, L.P.            310,781                  0.7%
            Baker Biotech Fund I, L.P.                3,058,088                  6.4%
            Baker Biotech Fund II, L.P.               2,809,462                  5.9%
            Baker Biotech Fund II (Z), L.P.             386,831                  0.8%
                                                   ------------                -----
            Total                                     7,312,500                 15.4%


           By  virtue  of their  ownership  of  entities  that have the power to
           control the investment  decisions of the limited  partnerships listed
           in the table above  (collectively,  the "Baker Entities"),  Julian C.
           Baker and Felix J. Baker may each be deemed to be  beneficial  owners
           of securities  owned by the Baker  Entities and may be deemed to have
           shared  power to vote or direct the vote and to dispose or direct the
           disposition of such securities,  although such entities have the sole
           right to receive and power to direct the receipt of  dividends  from,
           and the proceeds from the sale of, securities owned by them.

                                  Page 17 of 28




           Additionally, Felix J. Baker is a director of the Issuer.

           Delphi Reporting Persons

           Delphi Ventures  beneficially  owns 2,227,725  shares of the Issuer's
           Common Stock,  which  represents  5.3% of the Issuer's  Common Stock.
           Delphi BioInvestments beneficially owns 22,275 shares of the Issuer's
           Common Stock, which represents 0.01% of the Issuer's Common Stock.

           As the general partner of Delphi Ventures and Delphi  BioInvestments,
           Delphi  Management  may be  deemed  to  beneficially  own the  shares
           beneficially   owned  by  each  of   Delphi   Ventures   and   Delphi
           BioInvestments.

           The foregoing shall not be an admission that Delphi Management is the
           beneficial  owner of the shares held by Delphi Ventures and/or Delphi
           BioInvestments.

           The Reporting  Persons are party to a voting  agreement  contained in
           the Investors Rights Agreement  referred to in Item 6 below. The JPMP
           Reporting  Persons,  the  Baker  Reporting  Persons,  and the  Delphi
           Reporting  Persons together may be deemed to constitute a "group" for
           purposes of Section  13(d)(3) of the Act,  with respect to 16,875,000
           shares of Common Stock,  representing 29.6% of the outstanding voting
           power of the Issuer.

           Each  of  the  Reporting  Persons,   however,   disclaims  beneficial
           ownership  of any of the  securities  owned  by any  other  Reporting
           Person and disclaims  that it is a member of a "group" with any other
           persons  either for  purposes of Section  13(d)(3) of the Act or Rule
           13d-5  thereunder or this Statement or for any other purpose  related
           to its beneficial ownership of the Issuer's securities. The filing of
           this  Statement  shall  not be  construed  as an  admission  that the
           Reporting  Person is the beneficial  owner of such shares or that the
           Reporting Person and any of such other  stockholders'  constitute for
           purposes  of  Section  13(d) of the Act, a  "group."  Each  Reporting
           Person is not responsible  for the accuracy of any information  filed
           in this Statement  relating to any Reporting Person other than itself
           and its related persons or entities.

           There have been no  transactions  involving the Issuer's Common Stock
           during the past sixty days which are  required to be reported in this
           Statement.

           No person other than the JPMP Reporting Persons,  the Baker Reporting
           Persons and the Delphi Reporting  Persons has the right to receive or
           the power to direct the  receipt of  dividends  from or the  proceeds
           from the sale of the Issuer's Common Stock owned  beneficially by the
           JPMP Reporting  Persons,  the Baker Reporting  Persons and the Delphi
           Reporting Persons.

                                  Page 18 of 28




Item 6. Contracts, Arrangements, Understandings or Relationships With Respect to
Securities of the Issuer.

            On May 12, 2003 the Company  entered  into the  Securities  Purchase
            Agreement  (as amended by  Amendment  No. 1 dated as of May 14, 2003
            and Amendment No. 2 dated as of June 2, 2003) (the "SPA"), with JPMP
            (BHCA),  the  Global  Fund  Entities,  the  Baker  Entities,  Delphi
            Ventures, Delphi BioInvestments, entities affiliated with BA Venture
            Partners and T. Rowe Price Health Sciences Fund, Inc. (collectively,
            the "Series A Investors"). Both the SPA and all exhibits thereto are
            attached  as Exhibit A hereto and are  incorporated  herein in their
            entirety by reference.

            Pursuant to the SPA, the Issuer  issued in a private  placement  (a)
            1,640,000  shares of the Company's  Series A  Convertible  Preferred
            Stock (the "Preferred Stock") to the Series A Investors,  as well as
            the reservation  for issuance of 16,400,000  shares of the Company's
            Common  Stock  upon  conversion  of the  Preferred  Stock,  and  (b)
            warrants  (the  "Warrants")  to  purchase  2,050,000  shares  of the
            Company's Common Stock and the reservation for issuance of 2,050,000
            shares of the  Company's  Common  Stock  upon the  exercise  of such
            Warrants (together, the "Preferred Stock Financing").  The Preferred
            Stock has the rights,  preferences  and  privileges set forth in the
            Certificate of Designations of Series A Convertible  Preferred Stock
            as filed with the  Secretary of State of the State of Delaware.  The
            purchase  price for the Preferred  Stock was $25.00 per share.  Each
            share of Preferred Stock is initially  convertible into 10 shares of
            Common Stock at a fixed conversion price of $2.50 per share (subject
            to adjustment upon the occurrence of certain events  including stock
            subdivisions,   combinations,   splits,  stock  dividends,   capital
            reorganizations,  or capital reclassifications of the Common Stock),
            at such holder's  option at any time after the first  anniversary of
            the closing of the Investors Rights Agreement among the Company, the
            Reporting Persons and the other investors named therein, dated as of
            July 8, 2003, a copy of which is attached hereto as Exhibit B and is
            incorporated  herein in its  entirety by reference  (the  "Investors
            Rights Agreement").

            The Warrants are  immediately  exercisable at a fixed purchase price
            of $6.25 per share of Common Stock and expire on December 31, 2011.

                                  Page 19 of 28





           Pursuant to the Certificate of Designations  and the Investors Rights
           Agreement,  the Series A  Investors,  voting  together  as a separate
           class, have the right to designate two members of the Company's Board
           of  Directors  so long as at least  37.5% of the shares of  Preferred
           Stock issued at the closing of the Preferred Stock  Financing  remain
           outstanding.  If between  18.75% and 37.5% of the shares of Preferred
           Stock  issued at the closing of the  Preferred  Stock  Financing  are
           outstanding,  the Series A Investors,  voting  together as a separate
           class,  have the right to designate one member of the Company's Board
           of  Directors.  If less than 18.75% of the shares of Preferred  Stock
           issued  at  the  closing  of  the  Preferred   Stock   Financing  are
           outstanding,  the rights of the Series A Investors to vote separately
           for the election of directors shall terminate.

           Pursuant to the terms of the Investors Rights Agreement, one director
           will be  designated  by the JPMP  Reporting  Persons and one director
           will be  designated  by the  Baker  Entities.  The  right of the JPMP
           Reporting Persons and the Baker Entities, as applicable, to designate
           a  director  terminates  if the JPMP  Reporting  Persons or the Baker
           Entities,  as applicable,  hold less than 50% of the Preferred  Stock
           (or Common Stock issued upon conversion  thereof)  purchased by it at
           the  closing of the  Preferred  Stock  Financing.  Pursuant  to these
           rights,  the JPMP Reporting  Persons  designated  Srinivas  Akkaraju,
           M.D., Ph.D. as its representative on the Company's Board of Directors
           and  the  Baker  Entities   designated  Felix  Baker,  Ph.D.  as  its
           representative  on the Company's  Board of Directors upon the closing
           of the Preferred Stock Financing.  The Series A Investors do not have
           the right to vote on  members  of the  Company's  Board of  Directors
           other than the nominees they designate.

           Each of JPMP  (BHCA) and the Global  Fund  Entities is a party to the
           Regulatory  Sideletter,  dated as of July 8,  2003,  by and among the
           Company,  JPMP (BHCA) and each of the Global Fund Entities, a copy of
           which is attached as Exhibit C hereto and is  incorporated  herein in
           its entirety by reference.

ITEM 7.    MATERIAL TO BE FILED AS EXHIBITS.

           SCHEDULE A

           Item 2  information  for  executive  officers and  directors of JPMP
           Capital Corp.

           SCHEDULE B

           Item 2 information for executive  officers and directors of JPMorgan
           Chase.

           SCHEDULE C

           Item 2 information for managing members of Delphi Management.10*

           EXHIBIT A

           Securities Purchase Agreement dated as of May 12, 2003, by and among
           the Issuer and the Series A Investors  incorporated  by reference to
           Exhibit  10.1 of the Form 8-K filed with the  Commission  on May 15,
           2003.*

           EXHIBIT B

           Investors  Rights  Agreement  dated as of July 8, 2003, by and among
           the  Company  and  the  Investors  named  therein   incorporated  by
           reference  to Exhibit 4.2 of the Form 8-K filed with the  Commission
           on May 15, 2003.*

----------
* Filed previously
                                  Page 20 of 28



            EXHIBIT C

            Regulatory  Sideletter  dated as of July 8,  2003,  by and among the
            Company, JPMP (BHCA) and each of the Global Fund Entities.*

            EXHIBIT D

            Joint  Filing  Agreement  dated as of May 17,  2004  among  the JPMP
            Entities, the Bakers and the Delphi Entities.*

----------
* Filed previously

                                  Page 21 of 28



                                    SIGNATURE

                  After reasonable  inquiry and to the best of our knowledge and
belief,  we certify that the  information  set forth in this  Statement is true,
complete and correct.

Dated: February 14, 2005

                                      J.P. MORGAN PARTNERS (BHCA), L.P.

                                      By:      JPMP Master Fund Manager, L.P.,
                                               its general partner

                                      By:      JPMP Capital Corp.,
                                               its general partner

                                      By:      /s/ Jeffrey  C. Walker
                                               ---------------------------------
                                               Name:  Jeffrey C. Walker
                                               Title:  President

                                      J.P. MORGAN PARTNERS GLOBAL 
                                      INVESTORS, L.P.

                                      By:      JPMP Global Investors, L.P.,
                                               its general partner

                                      By:      JPMP Capital Corp.,
                                               its general partner

                                      By:      /s/ Jeffrey  C. Walker
                                               ---------------------------------
                                               Name:  Jeffrey C. Walker
                                               Title:  President

                                      J.P. MORGAN PARTNERS GLOBAL
                                      INVESTORS (CAYMAN), L.P.

                                      By:      JPMP Global Investors, L.P.,
                                               its general partner

                                      By:      JPMP Capital Corp.,
                                               its general partner

                                      By:      /s/ Jeffrey  C. Walker
                                               ---------------------------------
                                               Name:  Jeffrey C. Walker
                                               Title:  President

                                  Page 22 of 28



                                      J.P. MORGAN PARTNERS GLOBAL
                                      INVESTORS A, L.P.

                                      By:      JPMP Global Investors, L.P.,
                                               its general partner

                                      By:      JPMP Capital Corp.,
                                               its general partner

                                      By:      /s/ Jeffrey  C. Walker
                                               ---------------------------------
                                               Name:  Jeffrey C. Walker
                                               Title:  President

                                      J.P. MORGAN PARTNERS GLOBAL
                                      INVESTORS (SELLDOWN), L.P.

                                      By:      JPMP Global Investors, L.P.,
                                               its general partner

                                      By:      JPMP Capital Corp.,
                                               its general partner

                                      By:      /s/ Jeffrey  C. Walker
                                               ---------------------------------
                                               Name:  Jeffrey C. Walker
                                               Title:  President

                                  Page 23 of 28



                                      JULIAN C. BAKER

                                      By:     /s/  Julian C. Baker
                                              ----------------------------------
                                              Julian C. Baker

                                      FELIX J. BAKER

                                      By:     /s/ Felix J. Baker
                                              ----------------------------------
                                              Felix J. Baker

                                      DELPHI VENTURES VI, L.P.

                                      By:     Delphi Management Partners VI, 
                                              L.L.C., its general partner

                                      By:     /s/ Deepika R. Pakianathan
                                              ----------------------------------
                                              Deepika R. Pakianathan
                                              Managing Member

                                      DELPHI BIOINVESTMENTS VI, L.P.

                                      By:     Delphi Management Partners VI, 
                                              L.L.C., its general partner

                                      By:     /s/ Deepika R. Pakianathan
                                              ----------------------------------
                                              Deepika R. Pakianathan
                                              Managing Member

                                      DELPHI MANAGEMENT PARTNERS VI, L.L.C.

                                      By:     /s/ Deepika R. Pakianathan
                                              ----------------------------------
                                              Deepika R. Pakianathan
                                              Managing Member

                                  Page 24 of 28



                                                                      SCHEDULE A

                               JPMP CAPITAL CORP.

                              EXECUTIVE OFFICERS(1)

Chief Executive Officer                                 William B. Harrison**
President                                               Jeffrey C. Walker*
Chief Investment Officer                                Arnold L. Chavkin*
Managing Director                                       Srinivas Akkaraju*
Managing Director                                       Christopher Albinson*
Managing Director                                       Dr. Dana Beth Ardi*
Managing Director                                       Richard Aube*
Managing Director                                       Christopher C. Behrens*
Managing Director                                       John Breckenridge*
Managing Director                                       Julie Casella-Esposito*
Managing Director                                       Rodney A. Ferguson*
Managing Director                                       Cornell P. French*
Managing Director                                       Michael R. Hannon*
Managing Director                                       Matthew Lori*
Managing Director                                       Jonathan R. Lynch*
Managing Director                                       Bryan Martin*
Managing Director                                       Sunil Mishra*
Managing Director                                       Stephen P. Murray*
Managing Director                                       Timothy Purcell*
Managing Director                                       John Reardon*
Managing Director                                       Faith Rosenfeld*
Managing Director                                       Shahan D. Soghikian*
Managing Director                                       William Stuck*
Managing Director                                       Patrick J. Sullivan*
Managing Director                                       Timothy J. Walsh*
Managing Director                                       Richard D. Waters, Jr. *
Managing Director                                       Damion E. Wicker, M.D.*

                                   DIRECTORS*
                              William B. Harrison**
                               Jeffrey C. Walker*

----------

*     Each of whom is a United States citizen.
*     Principal  occupation is employee and/or officer of J.P. Morgan  Partners,
      LLC. Business address is c/o J.P. Morgan Partners, LLC, 1221 Avenue of the
      Americas, New York, New York 10020.
**    Principal  occupation  is  employee  or  officer of  JPMorgan  Chase & Co.
      Business  address is c/o JPMorgan Chase & Co., 270 Park Avenue,  New York,
      New York 10017.


                                  Page 25 of 28



                                                                      SCHEDULE B

                              JPMORGAN CHASE & CO.

                              EXECUTIVE OFFICERS(1)

Chairman of the Board and Chief Executive Officer       William B. Harrison Jr.*
President and Chief Operating Officer                   James Dimon*
Chief Information Officer                               Austin A. Adams*
Co-Chairman, Investment Bank                            Steven D. Black*
Chief Executive Officer, Card Services                  William I. Campbell*
Chief Financial Officer                                 Michael J. Cavanagh*
Chairman, West Coast Region                             David A. Coulter*
Director of Human Resources, Head of Real        
Estate/Facilities, General Services, Security           John J. Farrell*
Co-General Counsel                                      Joan Guggenheimer*
Director of Corporate Marketing and Communications      Frederick W. Hill*
Head, Commercial Banking                                Samuel Todd Maclin*
Head, Strategy and Business Development                 Jay Mandelbaum*
Co-General Counsel                                      William H. McDavid*
Chief Executive Officer, Treasury & Securities Services Heidi Miller*
Head, Retail Financial Services                         Charles W. Scharf*
Executive Vice President, Card Services                 Richard J. Srednicki*
Head, Asset & Wealth Management                         James E. Staley*
Chief Risk Officer                                      Don M. Wilson III*
Co-Chairman, Investment Bank                            William T. Winters*

----------
(1)   Each of whom is a United States citizen.

*     Principal  occupation  is  employee  or  officer of  JPMorgan  Chase & Co.
      Business  address is c/o JPMorgan Chase & Co., 270 Park Avenue,  New York,
      New York 10017.


                                  Page 26 of 28



                                   DIRECTORS*

 NAME                        PRINCIPAL OCCUPATION OR EMPLOYMENT;
                             BUSINESS OR RESIDENCE ADDRESS
--------------------------------------------------------------------------------
 Hans W. Becherer            Retired Chairman of the Board and
                             Chief Executive Officer
                             Deere & Company
                             c/o JPMorgan Chase & Co.
                             270 Park Avenue
                             New York, New York 10017
--------------------------------------------------------------------------------
 John H. Biggs               Former Chairman and CEO
                             TIAA - CREF
                             c/o JPMorgan Chase & Co.
                             270 Park Avenue
                             New York, New York 10017
--------------------------------------------------------------------------------
 Lawrence A. Bossidy          Retired Chairman of the Board
                             Honeywell International Inc.
                             c/o JPMorgan Chase & Co.
                             270 Park Avenue
                             New York, New York 10017
--------------------------------------------------------------------------------
 Stephen B. Burke            President
                             Comcast Cable Communications, Inc.
                             c/o JPMorgan Chase & Co.
                             270 Park Avenue
                             New York, New York 10017
--------------------------------------------------------------------------------
James S. Crown               President
                             Henry Crown and Company
                             c/o JPMorgan Chase & Co.
                             270 Park Avenue
                             New York, New York 10017
--------------------------------------------------------------------------------
James Dimon                  President and Chief Operating Officer
                             JPMorgan Chase & Co.
                             270 Park Avenue, 8th Floor
                             New York, New York 10017-2070
--------------------------------------------------------------------------------
Ellen V. Futter              President and Trustee
                             American Museum of Natural History
                             c/o JPMorgan Chase & Co.
                             270 Park Avenue
                             New York, New York 10017
--------------------------------------------------------------------------------
 William H. Gray, III        Retired President and Chief Executive Officer
                             The College Fund/UNCF
                             c/o JPMorgan Chase & Co.
                             270 Park Avenue
                             New York, New York 10017
--------------------------------------------------------------------------------

----------
*     Each of whom is a United States citizen.


                                  Page 27 of 28



 NAME                        PRINCIPAL OCCUPATION OR EMPLOYMENT;
                             BUSINESS OR RESIDENCE ADDRESS
--------------------------------------------------------------------------------

 William B. Harrison, Jr.    Chairman of the Board and Chief Executive Officer
                             JPMorgan Chase & Co.
                             270 Park Avenue, 8th Floor
                             New York, New York  10017-2070
--------------------------------------------------------------------------------
 Laban P. Jackson, Jr.       Chairman and Chief Executive Officer
                             Clear Creek Properties, Inc.
                             c/o JPMorgan Chase & Co.
                             270 Park Avenue
                             New York, New York 10017
--------------------------------------------------------------------------------
 Lee R. Raymond              Chairman of the Board and Chief Executive Officer
                             Exxon Mobil Corporation
                             c/o JPMorgan Chase & Co.
                             270 Park Avenue
                             New York, New York 10017
--------------------------------------------------------------------------------
 John W. Kessler             Owner
                             John W. Kessler Company
                             c/o JPMorgan Chase & Co.
                             270 Park Avenue
                             New York, New York 10017
--------------------------------------------------------------------------------
 Robert I. Lipp              Chairman
                             The St. Paul Travelers Companies, Inc.
                             c/o JPMorgan Chase & Co.
                             270 Park Avenue
                             New York, New York 10017
--------------------------------------------------------------------------------
 Richard A. Monoogian        Chairman and Chief Executive Officer
                             Masco Corporation
                             c/o JPMorgan Chase & Co.
                             270 Park Avenue
                             New York, New York 10017
--------------------------------------------------------------------------------
 David C. Novak              Chairman and Chief Executive Officer
                             Yum! Brands, Inc.
                             c/o JPMorgan Chase & Co.
                             270 Park Avenue
                             New York, New York 10017
--------------------------------------------------------------------------------
 John R. Stafford            Retired Chairman of the Board
                             Wyeth
                             c/o JPMorgan Chase & Co.
                             270 Park Avenue
                             New York, New York 10017
--------------------------------------------------------------------------------


                                  Page 28 of 28