UNITED STATES

SECURITIES AND EXCHANGE COMMISSION

Washington, D.C. 20549

o

Rule 13d-1(b)

o

Rule 13d-1(c)

x

Rule 13d-1(d)

CUSIP No. 09065 V 20 3

1

Names of Reporting Persons
Ross J. Mangano

2

Check the Appropriate Box if a Member of a Group (See Instructions)

(a)

o

(b)

o

3

SEC Use Only

4

Citizenship or Place of Organization
United States of America

Number of
Shares
Beneficially
Owned by
Each
Reporting
Person With

5

Sole Voting Power
2,289,582 (see Item 4)

6

Shared Voting Power
0

7

Sole Dispositive Power
2,289,582 (see Item 4)

8

Shared Dispositive Power
0 (see Item 4)

9

Aggregate Amount Beneficially Owned by Each Reporting Person
2,289,582 (see Item 4)

10

Check Box if the Aggregate Amount in Row (9) Excludes Certain Shares (See Instructions)  o
Not Applicable

11

Percent of Class Represented by Amount in Row (9)
8.5%

12

Type of Reporting Person (See Instructions)
IN

CUSIP No. 09065 V 20 3

1

Names of Reporting Persons
JO & Co.

2

Check the Appropriate Box if a Member of a Group (See Instructions)

(a)

o

(b)

o

3

SEC Use Only

4

Citizenship or Place of Organization
Indiana

Number of
Shares
Beneficially
Owned by
Each
Reporting
Person With

5

Sole Voting Power
1,909,661 (see Item 4)

6

Shared Voting Power
0

7

Sole Dispositive Power
1,909,661 (see Item 4)

8

Shared Dispositive Power
0 (see Item 4)

9

Aggregate Amount Beneficially Owned by Each Reporting Person
1,909,661 (see Item 4)

10

Check Box if the Aggregate Amount in Row (9) Excludes Certain Shares (See Instructions)  o
Not Applicable

11

Percent of Class Represented by Amount in Row (9)
7.1%

12

Type of Reporting Person (See Instructions)
CO

Item 1(a).

Name of Issuer:
The name of the issuer is BioSante Pharmaceuticals, Inc.

Item 1(b).

Address of Issuer’s Principal Executive Offices:
The address of the principal executive offices of BioSante is 111 Barclay Boulevard, Lincolnshire, Illinois 60069.

Item 2(a).

Name of Person Filing:
This Amendment No. 8 to Schedule 13G is being filed by and on behalf of Ross J. Mangano and JO & Co.

Item 2(b).

Address or Principal Business Office or, if none, Residence:
The address of Mr. Mangano’s and JO & Co.’s principal place of business is 112 West Jefferson Boulevard, Suite 613, South Bend, Indiana 46634.

Item 2(c).

Citizenship:
Mr. Mangano is a United States citizen and JO & Co. is an Indiana corporation.

Item 2(d).

Title of Class of Securities:
The class of equity securities to which this Statement relates is the common stock, $0.0001 par value per share, of BioSante Pharmaceuticals, Inc.

Item 2(e).

CUSIP Number:
The CUSIP number of the common stock is 09065 V 20 3.

Item 3.

If this statement is filed pursuant to Rules 13d-1(b), or 13d-2(b) or (c), check whether the person filing is a:

(a)

o

Broker or dealer registered under section 15 of the Securities Exchange Act of 1934 (the “Act”).

(b)

o

Bank, as defined in section 3(a)(6) of the Act.

(c)

o

Insurance company, as defined in section 3(a)(19) of the Act.

(d)

o

Investment company registered under section 8 of the Investment Company Act of 1940.

(e)

o

An investment advisor in accordance with Rule 13d-1(b)(1)(ii)(E).

(f)

o

An employee benefit plan or endowment fund in accordance with Rule 13d-1(b)(1)(ii)(F).

(g)

o

A parent holding company or control person, in accordance with Rule 13d-1(b)(ii)(G).

(h)

o

A savings association, as defined in Section 3(b) of the Federal Deposit Insurance Act.

(i)

o

A church plan, that is excluded from the definition of an investment company under section 3(c)(14) of the Investment Company Act of 1940.

(j)

o

A non-US institution in accordance with Rule 13d–1(b)(1)(ii)(J).

(k)

o

Group, in accordance with Rule 13d–1(b)(1)(ii)(K).

Item 4.

Ownership:

(a)

Amount beneficially owned:

Mr. Mangano’s beneficial ownership includes:  (1) 85,756 shares of common stock; (2) 49,166 shares of common stock issuable upon exercise of stock options exercisable within 60 days; (3) 1,909,661 shares of common stock held by JO & Co., of which Mr. Mangano is President, (4) 30,000 shares of common stock held by Oliver & Co., of which Mr. Mangano is the trustee and (6) an aggregate of 214,999 shares of common stock held in various accounts, of which Mr. Mangano is an advisor and/or a trustee.

JO & Co.’s beneficial ownership consists of 1,909,661 shares of common stock.

(b)

Percent of class:

8.5% for Mr. Mangano and 7.1% for JO & Co.  The foregoing percentages are calculated based on the 27,042,764 shares of common stock reported to be outstanding by BioSante on its most recently filed quarterly report on Form 10-Q for the quarter ended September 30, 2008.

(c)

Number of shares as to which Mr. Mangano has:

(i)

Sole power to vote or to direct the vote   

2,289,582

(ii)

Shared power to vote or to direct the vote    

0

(iii)

Sole power to dispose or to direct the disposition of   

2,289,582

(iv)

Shared power to dispose or to direct the disposition of   

0

Number of shares as to which JO & Co. has:

(i)

Sole power to vote or to direct the vote   

1,909,661

(ii)

Shared power to vote or to direct the vote    

0

(iii)

Sole power to dispose or to direct the disposition of   

1,909,661

(iv)

Shared power to dispose or to direct the disposition of   

0

Item 5.

Ownership of Five Percent or Less of a Class:

If this statement is being filed to report the fact that as of the date hereof the reporting person has ceased to be the beneficial owner of more than 5 percent of the class of securities, check the following:  o.

Item 6.

Ownership of More than Five Percent on Behalf of Another Person:

Not Applicable.

Item 7.

Identification and Classification of the Subsidiary Which Acquired the Security Being Reported on By the Parent Holding Company or Control Person:

Not Applicable.

Item 8.

Identification and Classification of Members of the Group:

Not Applicable.

Item 9.

Notice of Dissolution of Group:

Not Applicable.

Item 10.

Certifications:

Not Applicable.

Date:  February 1, 2009

/s/ Ross J. Mangano

Ross J. Mangano

JO & Co.

By:

  /s/ Ross J. Mangano

Ross J. Mangano

Its:

President