UNITED STATES

SECURITIES AND EXCHANGE COMMISSION

Washington, D.C. 20549

o

Rule 13d-1(b)

x

Rule 13d-1(c)

o

Rule 13d-1(d)

CUSIP No. 98973P101

1.

Names of Reporting Persons
Lehman Brothers Holdings Inc.

S.S. or I.R.S. Identification No. of Above Person
13-3216325

2.

Check the Appropriate Box if a Member of a Group (See Instructions)

(a)

o

(b)

o

3.

SEC Use Only

4.

Citizenship or Place of Organization
Delaware

Number of
Shares
Beneficially
Owned by
Each
Reporting
Person With

5.

Sole Voting Power
1,467,607(1) 

6.

Shared Voting Power
-0-

7.

Sole Dispositive Power
1,467,607(1)

8.

Shared Dispositive Power
-0-

9.

Aggregate Amount Beneficially Owned by Each Reporting Person
1,467,607(1)

10.

Check if the Aggregate Amount in Row (9) Excludes Certain Shares (See Instructions)  o

11.

Percent of Class Represented by Amount in Row (9)
6.8%(2)

12.

Type of Reporting Person (See Instructions)
HC/CO

CUSIP No. 98973P101

1.

Names of Reporting Persons
Lehman Brothers Inc.

S.S. or I.R.S. Identification No. of Above Person
13-2518466

2.

Check the Appropriate Box if a Member of a Group (See Instructions)

(a)

o

(b)

o

3.

SEC Use Only

4.

Citizenship or Place of Organization
Delaware

Number of
Shares
Beneficially
Owned by
Each
Reporting
Person With

5.

Sole Voting Power
1,467,607(1)

6.

Shared Voting Power
-0-

7.

Sole Dispositive Power
1,467,607(1)

8.

Shared Dispositive Power
-0-

9.

Aggregate Amount Beneficially Owned by Each Reporting Person
1,467,607(1)

10.

Check if the Aggregate Amount in Row (9) Excludes Certain Shares (See Instructions)  o

11.

Percent of Class Represented by Amount in Row (9)
6.8%(2)

12.

Type of Reporting Person (See Instructions)
BD/CO

CUSIP No. 98973P101

1.

Names of Reporting Persons
LB I Group Inc.

S.S. or I.R.S. Identification No. of Above Person
13-2741778

2.

Check the Appropriate Box if a Member of a Group (See Instructions)

(a)

o

(b)

o

3.

SEC Use Only

4.

Citizenship or Place of Organization
Delaware

Number of
Shares
Beneficially
Owned by
Each
Reporting
Person With

5.

Sole Voting Power
1,467,607(1)

6.

Shared Voting Power
-0-

7.

Sole Dispositive Power
1,467,607(1)

8.

Shared Dispositive Power
-0-

9.

Aggregate Amount Beneficially Owned by Each Reporting Person
1,467,607(1)

10.

Check if the Aggregate Amount in Row (9) Excludes Certain Shares (See Instructions)  o

11.

Percent of Class Represented by Amount in Row (9)
6.8%(2)

12.

Type of Reporting Person (See Instructions)
CO

Item 1.

(a)

Name of Issuer
Ziopharm Oncology, Inc.

(b)

Address of Issuer’s Principal Executive Offices
1180 Avenue of the Americas

19th Floor

New York, New York 10036

Item 2.

(a)

Name of Person Filing
Lehman Brother Holdings Inc.

Lehman Brothers Inc.

LB I Group Inc.

(b)

Address of Principal Business Office or, if none, Residence
Lehman Brothers Holdings Inc.

745 Seventh Avenue

New York, New York 10019

Lehman Brothers Inc.

745 Seventh Avenue

New York, New York 10019

LB I Group Inc.

399 Park Avenue

New York, New York 10022

(c)

Citizenship
Lehman Brothers Holdings Inc. (“Holdings”) is a corporation organized under the laws of the State of Delaware.

Lehman Brothers Inc. (“LBI”) is a corporation organized under the laws of the State of Delaware. LBI is a broker-dealer registered under Section 15 of the Act.

LB I Group Inc. (“LB I Group”) is a corporation organized under the laws of the State of Delaware.

(d)

Title of Class of Securities
Common Stock

(e)

CUSIP Number
98973P101

Item 3.

If this statement is filed pursuant to §§240.13d-1(b) or 240.13d-2(b) or (c), check whether the person filing is a:

(a)

o

A broker or dealer under Section 15 of the 1934 Act

(b)

o

A bank as defined in Section 3(a)(6) of the 1934 Act

(c)

o

An insurance company as defined in Section 3(a)(19) of the 1934 Act

(d)

o

An investment company registered under Section 8 of the Investment Company Act of 1940

(e)

o

An investment advisor in accordance with Rule 13d-1(b)(1)(ii)(E)

(f)

o

An employee benefit plan or endowment fund in accordance with Rule 13d-1(b)(1)(ii)(F)

(g)

o

A parent holding company or control person in accordance with Rule 13d-1(b)(1)(ii)(G)

(h)

o

A savings association as defined in Section 3(b) of the Federal Deposit Insurance Act

(i)

o

A church plan that is excluded from the definition of investment company under Section 3(c)(14)Of the Investment Company Act of 1940

(j)

o

A group, in accordance with Rule 13d-1(b)(1)(ii)(J)

Item 4.

Ownership

LB I Group owns 863,930 shares of Common Stock of the Issuer and 259,179 shares of Common Stock issuable pursuant to a warrant that is presently exercisable.

(a)

Amount beneficially owned:   

See Item 9 of cover pages.

(b)

Percent of class:   

See Item 11 of cover pages.

(c)

Number of shares as to which the person has:

(i)

Sole power to vote or to direct the vote   

(ii)

Shared power to vote or to direct the vote    

(iii)

Sole power to dispose or to direct the disposition of   

(iv)

Shared power to dispose or to direct the disposition of   

See Items 5-8 of cover pages.

Item 5.

Ownership of Five Percent or Less of a Class

If this statement is being filed to report the fact that as of the date hereof the reporting person has ceased to be the beneficial owner of more than five percent of the class of securities, check the following   o.

Item 6.

Ownership of More than Five Percent on Behalf of Another Person

Not Applicable

Item 7.

Identification and Classification of the Subsidiary Which Acquired the Security Being Reported on By the Parent Holding Company or Control Person

LB I Group is the actual owner of the shares of common stock and warrants reported herein.  LB I Group is a wholly-owned subsidiary of LBI, which is a wholly-owned subsidiary of Holdings.

Under the rules and regulations of the Securities and Exchange Commission, both LBI and Holdings may be deemed to be the beneficial owners of the shares of common stock and warrants owned by LB I Group.

Item 8.

Identification and Classification of Members of the Group

Not Applicable

Item 9.

Notice of Dissolution of Group

Not Applicable

Item 10.

Certification

o

By signing below I certify that, to the best of my knowledge and belief, the securities referred to above were acquired and are held in the ordinary course of business and were not acquired and are not held for the purpose of or with the effect of changing or influencing the control of the issuer of the securities and were not acquired and are not held in connection with or as a participant in any transaction having that purpose or effect.

x

By signing below I hereby certify that, to the best of my knowledge and belief, the securities referred to above were not acquired and are not held for the purpose of or with the effect of changing or influencing the control of the issuer of the securities and were not acquired and are not held in connection with or as a participant in any transaction having that purpose or effect.

February 13, 2008

Date

LEHMAN BROTHERS HOLDINGS INC.

/s/ Barrett S. DiPaolo

Signature

Barrett S. DiPaolo
Vice President

Name/Title

LEHMAN BROTHERS INC.

/s/ Barrett S. DiPaolo

Signature

Barrett S. DiPaolo
Senior Vice President

Name/Title

LB I GROUP INC.

/s/ Barrett S. DiPaolo

Signature

Barrett S. DiPaolo
Authorized Signatory

Name/Title