SECURITIES AND EXCHANGE COMMISSION
                             Washington, D.C. 20549

                                  Schedule 13G

                    Under the Securities Exchange Act of 1934
                               (Amendment No. 1)



                                  ArQule, Inc.
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                                (Name of Issuer)


                                  Common Stock
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                         (Title of Class of Securities)


                                   04269E 10 7
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                                 (CUSIP Number)


                                  May 21, 2001
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             (Date of Event which Requires Filing of this
Statement)


Check the  appropriate box to designate the rule pursuant to
which this
Schedule is filed:

[ ]     Rule 13d-1(b)

[X]     Rule 13d-1(c)

[ ]     Rule 13d-1(d)

                         (Continued on following pages)



                              Page 1 of 11 Pages
                       Exhibit Index Contained on Page 10



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CUSIP NO. 04269E 10 7                13 G                   Page
2 of 11 pages
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1            NAME OF REPORTING ENTITY
                                                          John
Shoch ("Shoch")
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2            CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*
                                                      (a)  [ ]
(b) [X]
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3            SEC USE ONLY
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4            CITIZENSHIP OR PLACE OF ORGANIZATION

United States
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             NUMBER OF               5        SOLE VOTING POWER
              SHARES                          21,235 shares.
           BENEFICIALLY
           OWNED BY EACH
             REPORTING
              PERSON
               WITH
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--------------


                                     6        SHARED VOTING
POWER
                                              81,099 shares are
owned by
                                              AMA98 Ventures,
L.P.; 9,731
                                              shares are owned
by AMA98
                                              Corporate, L.P.;
44,463 shares
                                              are owned by AMA98
Investors,
                                              L.P.; 17,908
shares are owned by
                                              AMA98 Partners,
L.P. The general
                                              partner of each of
these
                                              entities is Alloy
Ventures 1998,
                                              LLC, of which
Shoch is a
                                              managing member.
33,659 shares
                                              are owned by Asset
Management
                                              Associates 1996,
L.P., the
                                              general partner of
which is AMC
                                              Partners 96, L.P.
Shoch is a
                                              general partner of
AMC
                                              Partners 96, L.P.
Shoch may be
                                              deemed to have a
shared power to
                                              vote the shares
described
                                              therein.
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                                     7        SOLE DISPOSITIVE
POWER

                                              see response to
item 5
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--------------


                                     8        SHARED VOTING
POWER

                                              see response to
item 6
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--------------

9            AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH
             REPORTING PERSON
208,095
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10           CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9)
             EXCLUDES CERTAIN SHARES*
[ ]
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11           PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9

1.0%
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12           TYPE OF REPORTING PERSON*

IN
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[FN]

                           *   SEE INSTRUCTIONS BEFORE FILLING
OUT!



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CUSIP NO. 04269E 10 7                13 G                   Page
3 of 11 pages
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1            NAME OF REPORTING ENTITY
                                                       Craig
Taylor ("Taylor")
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2            CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*
                                                      (a)  [ ]
(b) [X]
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3            SEC USE ONLY
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4            CITIZENSHIP OR PLACE OF ORGANIZATION

United States
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             NUMBER OF               5        SOLE VOTING POWER
              SHARES                          30,040 shares.
           BENEFICIALLY
           OWNED BY EACH
             REPORTING
              PERSON
               WITH
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                                     6        SHARED VOTING
POWER
                                              81,099 shares are
owned by
                                              AMA98 Ventures,
L.P.; 9,731
                                              shares are owned
by AMA98
                                              Corporate, L.P.;
44,463 shares
                                              are owned by AMA98
Investors,
                                              L.P.; 17,908
shares are owned by
                                              AMA98 Partners,
L.P. The general
                                              partner of each of
these
                                              entities is Alloy
Ventures 1998,
                                              LLC, of which
Taylor is a
                                              managing member.
33,659 shares
                                              are owned by Asset
Management
                                              Associates 1996,
L.P., the
                                              general partner of
which is AMC
                                              Partners 96, L.P.
Taylor is a
                                              general partner of
AMC
                                              Partners 96, L.P.
Taylor may be
                                              deemed to have a
shared power to
                                              vote the shares
described
                                              therein.
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--------------


                                     7        SOLE DISPOSITIVE
POWER

                                              see response to
item 5
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--------------


                                     8        SHARED VOTING
POWER

                                              see response to
item 6
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9            AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH
             REPORTING PERSON
216,900
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10           CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9)
             EXCLUDES CERTAIN SHARES*
[ ]
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11           PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9

1.1%
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12           TYPE OF REPORTING PERSON*

IN
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[FN]


                     * SEE INSTRUCTIONS BEFORE FILLING OUT!



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CUSIP NO. 04269E 10 7                13 G                   Page
4 of 11 pages
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1            NAME OF REPORTING ENTITY
                                                    Douglas E.
Kelly ("Kelly")
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2            CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*
                                                      (a)  [ ]
(b) [X]
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3            SEC USE ONLY
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4            CITIZENSHIP OR PLACE OF ORGANIZATION

United States
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             NUMBER OF               5        SOLE VOTING POWER
              SHARES                          6,909 shares.
           BENEFICIALLY
           OWNED BY EACH
             REPORTING
              PERSON
               WITH
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                                     6        SHARED VOTING
POWER
                                              81,099 shares are
owned by
                                              AMA98 Ventures,
L.P.; 9,731
                                              shares are owned
by AMA98
                                              Corporate, L.P.;
44,463 shares
                                              are owned by AMA98
Investors,
                                              L.P.; 17,908
shares are owned by
                                              AMA98 Partners,
L.P. The general
                                              partner of each of
these
                                              entities is Alloy
Ventures 1998,
                                              LLC, of which
Kelly is a
                                              managing member.
33,659 shares
                                              are owned by Asset
Management
                                              Associates 1996,
L.P., the
                                              general partner of
which is AMC
                                              Partners 96, L.P.
Kelly is a
                                              general partner of
AMC
                                              Partners 96, L.P.
Kelly may be
                                              deemed to have a
shared power to
                                              vote the shares
described
                                              therein.
----------------------------------------------------------------
--------------


                                     7        SOLE DISPOSITIVE
POWER

                                              see response to
item 5
----------------------------------------------------------------
--------------


                                     8        SHARED VOTING
POWER

                                              see response to
item 6
----------------------------------------------------------------
--------------

9            AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH
             REPORTING PERSON
193,769
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--------------

10           CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9)
             EXCLUDES CERTAIN SHARES*
[ ]
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--------------

11           PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9

1.0%
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12           TYPE OF REPORTING PERSON*

IN
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--------------

[FN]


                     * SEE INSTRUCTIONS BEFORE FILLING OUT!



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CUSIP NO. 04269E 10 7                13 G                   Page
5 of 11 pages
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1            NAME OF REPORTING ENTITY
                                                      Tony Di
Bona ("Di Bona")
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2            CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*
                                                      (a)  [ ]
(b) [X]
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3            SEC USE ONLY
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4            CITIZENSHIP OR PLACE OF ORGANIZATION

Australia
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             NUMBER OF               5        SOLE VOTING POWER
              SHARES                          3,010 shares.
           BENEFICIALLY
           OWNED BY EACH
             REPORTING
              PERSON
               WITH
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--------------


                                     6        SHARED VOTING
POWER
                                              81,099 shares are
owned by
                                              AMA98 Ventures,
L.P.; 9,731
                                              shares are owned
by AMA98
                                              Corporate, L.P.;
44,463 shares
                                              are owned by AMA98
Investors,
                                              L.P.; 17,908
shares are owned by
                                              AMA98 Partners,
L.P. The general
                                              partner of each of
these
                                              entities is Alloy
Ventures 1998,
                                              LLC, of which Di
Bona is a
                                              managing member.
33,659 shares
                                              are owned by Asset
Management
                                              Associates 1996,
L.P., the
                                              general partner of
which is AMC
                                              Partners 96, L.P.
Di Bona is a
                                              general partner of
AMC
                                              Partners 96, L.P.
Di Bona may be
                                              deemed to have a
shared power to
                                              vote the shares
described
                                              therein.
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--------------


                                     7        SOLE DISPOSITIVE
POWER

                                              see response to
item 5
----------------------------------------------------------------
--------------


                                     8        SHARED VOTING
POWER

                                              see response to
item 6
----------------------------------------------------------------
--------------

9            AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH
             REPORTING PERSON
189,870
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--------------

10           CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9)
             EXCLUDES CERTAIN SHARES*
[ ]
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11           PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9

0.9%
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12           TYPE OF REPORTING PERSON*

IN
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--------------
[FN]


                     * SEE INSTRUCTIONS BEFORE FILLING OUT!




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CUSIP NO. 04269E 10 7                13 G                   Page
6 of 11 pages
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ITEM 1(A).        NAME OF ISSUER

                  Arqule, Inc.

ITEM 1(B).        ADDRESS OF ISSUER'S PRINCIPAL EXECUTIVE
OFFICES

                  19 Presidential Way
                  Woburn, Massachusetts 01801

ITEM 2(A).        NAME OF PERSONS FILING

                  This Statement is filed by John Shoch
("Shoch"), Craig
Taylor ("Taylor"), Douglas E. Kelly ("Kelly"), and Tony Di Bona
("Di Bona").
The foregoing entities and individuals are collectively referred
to as the
"Reporting Persons."

                  AMC Partners 96, L.P. is the general partner
of Asset
Management Associates 1996, L.P.  Shoch, Taylor, Kelly and Di
Bona are
general partners of AMC Partners 96, L.P.  Shoch, Taylor, Kelly
and Di Bona
may be deemed to have indirect beneficial ownership of shares of
the issuer
owned directly by Asset Management Associates 1996, L.P.

                  Alloy Ventures 1998, LLC is the general
partner of
AMA98 Ventures, L.P., AMA98 Corporate, L.P., AMA98 Investors,
L.P. and
AMA98 Partners, L.P. Shoch, Taylor, Kelly and Di Bona are the
managing
members of Alloy Ventures 1998, LLC.  Shoch, Taylor, Kelly and
Di Bona
may be deemed to have indirect beneficial ownership of shares of
the issuer
owned directly by AMA98 Ventures, L.P., AMA98 Corporate, L.P.,
AMA98
Investors, L.P. and AMA98 Partners, L.P.

                  Shoch, Taylor, Kelly and Di Bona hereby
disclaim beneficial
ownership of shares of issuer directly owned by Asset Management
Associates
1996, L.P., AMA98 Ventures, L.P., AMA98 Corporate, L.P., AMA98
Investors, L.P.
and AMA98 Partners, L.P. except to the extent of any indirect
pecuniary
interest therein.

ITEM 2(B).        ADDRESS OF PRINCIPAL OFFICE

                  The address for each of the Reporting Persons
is:

                  Alloy Ventures.
                  480 Cowper Street, 2nd Floor.
                  Palo Alto, CA  94301

ITEM 2(C)         CITIZENSHIP

                  Shoch, Taylor, and Kelly are all United States
citizens.
                  Di Bona is an Australian citizen.

ITEM 2(D) AND (E). TITLE OF CLASS OF SECURITIES AND CUSIP NUMBER

                  Common Stock
                  CUSIP # 04269E 10 7



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CUSIP NO. 04269E 10 7                13 G                   Page
7 of 11 pages
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ITEM 3.  Not Applicable

ITEM 4.  OWNERSHIP

            (a) Amount beneficially owned:

                See Row 9 of cover page for each Reporting
Person.

            (b) Percent of Class:

                See Row 11 of cover page for each Reporting
Person.

            (c) Number of shares as to which such person has:

                   (i)  Sole power to vote or to direct the
vote:

                        See Row 5 of cover page for each
Reporting Person.

                   (ii) Shared power to vote or to direct the
vote:

                        See Row 6 of cover page for each
Reporting Person.

                  (iii) Sole power to dispose or to direct the
disposition of:

                        See Row 7 of cover page for each
Reporting Person.

                   (iv) Shared power to dispose or to direct the
disposition
                        of:

                        See Row 8 of cover page for each
Reporting Person.

ITEM 5.  OWNERSHIP OF FIVE PERCENT OR LESS OF A CLASS


          If this statement is being filed to report the fact
that as of the
date hereof the reporting person has ceased to be the beneficial
owner of more
than five percent of the class of securities, check the
following [X].


ITEM 6.  OWNERSHIP OF MORE THAN FIVE PERCENT ON BEHALF OF
ANOTHER PERSON.

        Under certain circumstances set forth in the limited
partnership
agreements of Asset Management Associates 1996, L.P., AMA98
Ventures, L.P.,
AMA98 Corporate, L.P., AMA98  Investors, L.P. and AMA98
Partners, L.P. the
general and limited partners of each of such entities may be
deemed to have
the right to receive dividends from, or the proceeds from, the
sale of
shares of the issuer owned by each such entity of which they are
a partner.




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CUSIP NO. 04269E 10 7                13 G                   Page
8 of 11 pages
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ITEM 7.  IDENTIFICATION  AND CLASSIFICATION OF THE SUBSIDIARY
WHICH ACQUIRED
         THE SECURITY BEING REPORTED ON BY THE PARENT HOLDING
COMPANY

         Not applicable

ITEM 8.  IDENTIFICATION AND CLASSIFICATION OF MEMBERS OF THE
GROUP.

         Not applicable

ITEM 9.  NOTICE OF DISSOLUTION OF GROUP.

         Not applicable

ITEM 10. CERTIFICATION.

         Not applicable







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CUSIP NO. 04269E 10 7                13 G                   Page
9 of 11 pages
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                                   SIGNATURES

         After  reasonable  inquiry and to the best of our
knowledge and
belief, we certify that the  information  set forth in this
statement is
true, complete and correct.

Dated:   May 31, 2001


                                   /s/ John Shoch
                                   -----------------------------
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                                   JOHN SHOCH


                                   /s/ Craig Taylor
                                   -----------------------------
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                                   CRAIG TAYLOR


                                   /s/ Douglas E. Kelly
                                   -----------------------------
-------------
                                   DOUGLAS E. KELLY


                                   /s/ Tony Di Bona
                                   -----------------------------
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                                   TONY DI BONA






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CUSIP NO. 04269E 10 7                13 G                  Page
10 of 11 pages
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                                  EXHIBIT INDEX



Found on

Sequentially
Exhibit
Numbered Page
- -------
-------------

Exhibit A:  Agreement of Joint Filing
Page 11








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CUSIP NO. 04269E 10 7                13 G                  Page
11 of 11 pages
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                                    EXHIBIT A



                            Agreement of Joint Filing

                  The  undersigned  hereby agree that a single
Schedule 13G
(or any amendment thereto) relating to the Common Stock of
Arqule, Inc.
shall be filed on behalf of each of the  undersigned  and that
this Agreement
shall be filed as an exhibit to such Schedule 13G.

         Executed this 31st day of May, 2001.


                                   /s/ John Shoch
                                   -----------------------------
-------------
                                   JOHN SHOCH


                                   /s/ Craig Taylor
                                   -----------------------------
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                                   CRAIG TAYLOR


                                   /s/ Douglas E. Kelly
                                   -----------------------------
-------------
                                   DOUGLAS E. KELLY


                                   /s/ Tony Di Bona
                                   -----------------------------
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                                   TONY DI BONA